Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats.
Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats.
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DOI：
10.1152/ajpendo.1990.258.4.e673
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发表时间：
1990-04
期刊：
影响因子：
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通讯作者：
R. T. Turner;E. Lifrak;M. Beckner;G. Wakley;K. Hannon;L. Parker
中科院分区：
文献类型：
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作者：
R. T. Turner;E. Lifrak;M. Beckner;G. Wakley;K. Hannon;L. Parker
本实验观察了脱氢表雄酮(DHA)对正常大鼠和去卵巢大鼠胫骨骨干皮质骨和松质骨的影响。卵巢切除后10wk和16wk，血浆总DHA明显降低。将正常大鼠和去卵巢大鼠每月植入含有2.5 mg DHA或安慰剂的控释微丸皮下。DHA处理的正常大鼠血浆DHA升高，而激素处理的去卵巢大鼠血浆DHA接近正常。卵巢切除导致严重的松质骨骨量减少，在DHA治疗的动物中这种情况有所减轻。去卵巢大鼠骨干横截面积和皮质面积增加，DHA处理不能改变这一变化。去卵巢后16wk，胫骨骨干骨内膜和骨膜表面的骨形成减少，DHA治疗似乎拮抗了这些变化。我们将这些结果解释为外周DHA水平降低导致去卵巢大鼠骨骼改变的证据。
The effects of dehydroepiandrosterone (DHA) on cortical bone at the tibial diaphysis and cancellous bone at the tibial metaphysis were determined in intact and ovariectomized rats. Total plasma DHA was reduced at 10 and 16 wk after ovariectomy. Intact and ovariectomized rats were implanted monthly with controlled-release subcutaneous pellets containing 2.5 mg of DHA or placebo. Plasma DHA was elevated in DHA-treated intact rats and was near normal in hormone-treated ovariectomized rats. Ovariectomy resulted in severe cancellous bone osteopenia, which was reduced in DHA-treated animals. Cross-sectional and cortical areas were increased at the diaphysis in ovariectomized rats, and this was not altered by DHA treatment. Bone formation at the endosteal and periosteal surfaces of the tibial diaphysis was decreased 16 wk after ovariectomy, and DHA treatment appeared to antagonize these changes. We interpret these results as evidence that decreased peripheral DHA levels contribute to the skeletal changes in ovariectomized rats.