Rearrangement and expression of immunoglobulin genes in transgenic mice.
Rearrangement and expression of immunoglobulin genes in transgenic mice.
复制标题
转基因小鼠中免疫球蛋白基因的重排和表达。
DOI：
10.1007/978-3-642-77633-5_16
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发表时间：
1992
影响因子：
--
通讯作者：
Brinster,R
中科院分区：
文献类型：
--
作者：
Storb,U;Engler,P;Klotz,E;Weng,A;Haasch,D;Pinkert,C;Doglio,L;Glymour,M;Brinster,R
Transgenic mice are discussed which carry a rearrangment test transgene. The methylation status of the transgene varies, depending on the background mouse strain. When the transgene is bred into the C57BL/6 strain, it is completely methylated and not rearranged in lymphoid organs. After several generations of crossing into DBA/2 or SJL the transgene becomes unmethylated and rearranges at high frequency. A strain specific modifier of DNA methylation (Ssm-1) was mapped close to the Friend virus susceptibility locus (Fv-1) on mouse chromosome 4.
