ELECTROENCEPHALOGRAPHIC SPIKING ACTIVITY, DRUG LEVELS, AND SEIZURE OCCURRENCE IN EPILEPTIC PATIENTS
ELECTROENCEPHALOGRAPHIC SPIKING ACTIVITY, DRUG LEVELS, AND SEIZURE OCCURRENCE IN EPILEPTIC PATIENTS
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DOI：
10.1002/ana.410170612
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发表时间：
1985-01-01
影响因子：
11.2
通讯作者：
MARCIANI, MG
中科院分区：
文献类型：
--
作者：
GOTMAN, J;MARCIANI, MG
本文对44例局灶性癫痫患者的脑电图（EEG）峰电位与药物浓度及发作的关系进行了研究。通过个人或视频记录连续监测癫痫发作的发生，并通过自动检测方法量化尖峰速率。结果表明，药物水平不影响峰化率，峰化率在癫痫发作前没有变化，但在癫痫发作后显着增加，特别是继发性全身性癫痫发作。这种增加可以持续几天，并在清醒和睡眠期间观察到。高或低的尖峰率不影响癫痫发作的发生。发作间期的棘波可能被动地反映了大脑的损伤，这种损伤会因进一步的癫痫发作而恶化。峰值可能与癫痫发作无直接关系。
The relationships among the EEG spiking rate, drug levels and seizure occurrence in 44 patients with focal epilepsy were investigated. Seizure occurrence was continuously monitored by personal or videorecording and spiking rate was quantified by an automatic detection method. Results indicate that drug levels do not influence spiking rate and spiking rate does not change before seizures but increases markedly after them, particularly secondarily generalized seizures. This increase can last several days and is observed during wakefulness and sleep. High or low spiking rates do not influence the occurrence of seizures. Interictal spikes may passively reflect damage to the brain, a damage which is worsened by further seizures. Spikes may not be directly related to seizure generation.