Magnetoneurography of evoked compound action currents in human cervical nerve roots
Magnetoneurography of evoked compound action currents in human cervical nerve roots
复制标题
人颈神经根诱发复合动作电流的神经磁图
DOI：
10.1016/s1388-2457(00)00530-7
复制
发表时间：
2001
影响因子：
4.7
通讯作者：
G. Curio
中科院分区：
文献类型：
--
作者：
B. Mackert;M. Burghoff;Lars;M. Nordahn;P. Marx;L. Trahms;G. Curio
目的建立神经磁图（MNG）测量方案，允许非侵入性定位和追踪沿人体颈神经根传播的诱发复合动作电流。方法在磁屏蔽室内，对健康受试者的正中或双尺神经进行常规交替电刺激。使用多通道 SQUID 探测器记录诱发的磁反应，探测器的平面测量区域位于颈部中心。同时，使用颈部双极电极蒙太奇记录表面电位。结果在正中（尺）神经刺激时，检测到振幅高达 20 fT (10 fT) 的体感诱发磁场在颈部经椎间孔根部入口区传播，相应的表面电位为 1.5 μV (0.5 μV)。此外，正中神经刺激实验中时空磁场映射的信噪比允许偶极源重建并追踪复合动作电流沿神经根纤维的传播。结论神经磁图允许以毫秒时间和高空间分辨率追踪健康受试者中诱发复合动作电流沿颈根的传播。因此，MNG 提供了适合作为定位颈神经根局灶性神经病变的临床诊断工具的灵敏度。
ObjectiveA measurement protocol for magnetoneurography (MNG) is established which allows the non-invasive localization and tracing of evoked compound action currents propagating along cervical nerve roots in man.MethodsInside a magnetically shielded room either both median or both ulnar nerves of healthy subjects were conventionally electrostimulated in alternation. Evoked magnetic responses were recorded using a multichannel SQUID-detector with a planar measuring area centered over the neck. Simultaneously, electric surface potentials were recorded using cervical bipolar electrode montages.ResultsUpon median (ulnar) nerve stimulation somatosensory evoked magnetic fields up to 20 fT (10 fT) amplitude were detected propagating over the cervical transforaminal root entry zone, with corresponding electrical surface potentials of 1.5 μV (0.5 μV). Furthermore, the signal-to-noise ratio of the spatiotemporal magnetic field mappings in median nerve stimulation experiments allowed dipolar source reconstructions and tracing of the propagation of the compound action currents along nerve root fibers.ConclusionMagnetoneurography allows tracing of the propagation of evoked compound action currents along cervical roots in healthy subjects with millisecond temporal and high spatial resolution. Thus, MNG offers a sensitivity appropriate to serve as a clinical diagnostic tool for localizing focal neuropathies of cervical nerve roots.