Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma
Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma
复制标题
DOI：
10.1016/s0046-8177(97)90261-6
复制
发表时间：
1997-10-01
期刊：
影响因子：
3.3
通讯作者：
Serrano, S
中科院分区：
文献类型：
--
作者：
Moysset, I;Lloreta, J;Serrano, S
本文报告1例胸腺瘤合并机会性感染、CD_4/CD_8 T淋巴细胞失衡、低CD_4阳性T淋巴细胞计数和无HIV感染的卡波西肉瘤(KS)。部分KS梭形细胞和内皮细胞胞核内可见巨细胞病毒包涵体。众所周知，KS在艾滋病患者中的患病率很高，有时还与其他免疫抑制原因有关。在以前的研究中，共存的KS和胸腺瘤与重症肌无力、皮质类固醇治疗和CDS阳性T淋巴细胞计数过多有关。最近发现了与胸腺瘤相关的CD4和CD8阳性T淋巴细胞之间的失衡。本病例提示胸腺瘤、CD4阳性淋巴细胞减少症和KS之间可能存在一定的关系。版权所有(C)1997，由W.B.Saunders公司提供。
A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endo thelial cells. It is known that KS has a high prevalence in AIDS patients and has occasionally been associated with other causes of immunosuppression. In previous studies, coexisting KS and thymoma were related to myasthenia gravis, corticosteroid treatment and excess CDS-positive T-lymphocyte counts. More recently an imbalance between CD4 and CD8 positive T lymphocytes has been identified in association,vith thymoma. The present case suggests that there may be a relationship between thymoma, CD4-positive lymphopenia, and KS. Copyright (C) 1997 by W.B. Saunders Company.