FtsZ, a tubulin homologue in prokaryote cell division
FtsZ, a tubulin homologue in prokaryote cell division
复制标题
DOI：
10.1016/s0962-8924(97)01108-2
复制
发表时间：
1997-09-01
影响因子：
19
通讯作者：
Erickson, HP
中科院分区：
文献类型：
--
作者：
Erickson, HP
序列比对令人信服地证明FtsZ是真核微管蛋白的原核同源物。FtsZ似乎在真细菌和古细菌中是普遍的，并且也已在叶绿体中被鉴定。像微管蛋白一样，它似乎具有细胞骨架作用，因为这两种蛋白质在体外组装成两种类型的特征聚合物-原丝片和微环。免疫荧光和绿色荧光蛋白的使用的最新进展提供了清晰的图像FtsZ定位在一个环中的septation网站在细菌中，和新的见解组装这个Z-环。
Sequence alignments convincingly demonstrate that FtsZ is a prokaryotic homologue of eukaryotic tubulins. FtsZ appears to be universal in eubacteria and archaebacteria and has also been identified in chloroplasts. Like tubulin, it appears to have a cytoskeletal role as both proteins assemble into two types of characteristic polymers in vitro-protofilament sheets and mini-rings. Recent advances in immunofluorescence and the use of green fluorescent protein have provided clear images of FtsZ localized in a ring at the septation site in bacteria, and new insights into assembly of this Z-ring.