The effects of cooling the area postrema of male rats on conditioned taste aversions induced by LiC1 and apomorphine.
The effects of cooling the area postrema of male rats on conditioned taste aversions induced by LiC1 and apomorphine.
复制标题
冷却雄性大鼠后部区域对 LiC1 和阿朴吗啡诱导的条件性味觉厌恶的影响。
DOI：
10.1016/s0166-4328(97)80984-9
复制
发表时间：
1997
影响因子：
2.7
通讯作者：
Chambers,KC
中科院分区：
文献类型：
--
作者：
Wang,Y;Lavond,DG;Chambers,KC
尽管永久性损伤研究表明，化学感受器触发区最后区(AP)是条件性味道厌恶(CTA)的神经机制的一部分，但其确切作用仍有疑问。有人认为，AP永久性损伤后CTA获得的减弱是由于无法将条件味觉识别为新的味道。目前的一系列实验旨在测试AP的损伤干扰LiCl处理而不是对味道新颖性的识别的假设。这是通过使用可逆性损伤程序，冷却，仅在给药期间致病。在实验中。1，测量AP中冷探针尖端周围的热线表明，我们的降温程序允许AP的大部分降温到抑制神经元活动和跨突触传递的温度，但不抑制轴突传递。摘录。2和3，大鼠饮用10%蔗糖溶液后注射氯化锂或阿朴吗啡。AP在注射致病药物前5分钟开始降温，注射后继续降温55分钟。随后对大鼠进行习得测试，同时保留AP的神经功能。我们的实验结果表明，降温AP可以减弱LiCl诱导的CTA，但对阿朴吗啡诱导的CTA没有影响。由于大鼠在条件作用前后遇到新的蔗糖溶液时AP是功能的，而给予LiCl时AP不是功能的，这些结果不支持味觉新颖性假说的认识。
Although permanent lesion studies have demonstrated that the area postrema (AP), a chemoreceptor trigger zone, is part of the neural mechanism for conditioned taste aversions (CTAs), its exact role remains questionable. It has been suggested that the attenuated acquisition of a CTA after permanent lesions of the AP is the result of an inability to recognize the conditioned taste as novel. The present series of experiments was designed to test the hypothesis that lesions of the AP interfered with LiCl processing and not recognition of taste novelty. This was accomplished by using the reversible lesioning procedure, cooling, only during administration of the illness-inducing agent. In Expt. 1, measurement of thermal lines around the tip of the cold probe in the AP indicated that our cooling procedures allowed the majority of the AP to be cooled to temperatures that suppress neuronal activity and transsynaptic transmission, but not axonal transmission. In Expts. 2 and 3, rats were injected with either LiCl or apomorphine after consumption of a 10% sucrose solution. Cooling of the AP was initiated 5 min before administration of one of the illness-inducing agents and was continued for 55 min after injection. The rats were tested later for acquisition while the neural function of the AP was preserved. Our experimental results demonstrated that cooling the AP could attenuate the CTA induced by LiCl, but had no effect on the CTA induced by apomorphine. Since the AP was functional when the rats encountered the novel sucrose solution both before and after conditioning, but not functional when LiCl was given, these results do not support the recognition of taste novelty hypothesis.