Preclinical Assessment of a Zwitterionic Tantalum Oxide Nanoparticle X-ray Contrast Agent
Preclinical Assessment of a Zwitterionic Tantalum Oxide Nanoparticle X-ray Contrast Agent
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DOI：
10.1021/nn300928g
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发表时间：
2012-08-01
期刊：
影响因子：
17.1
通讯作者：
Marino, Michael E.
中科院分区：
文献类型：
--
作者：
Bonitatibus, Peter J., Jr.;Torres, Andrew S.;Marino, Michael E.
氧化钽纳米粒子作为下一代X射线造影剂显示出巨大的潜力。最近，我们报道了氧化钽纳米颗粒的进展，并确定了这些颗粒进一步发展所需的改进。也就是说，浓缩颗粒的粘度、网状内皮（RES）组织中的滞留量以及给药后大量颗粒对肾脏的影响都被确定为关键因素，需要进一步研究、理解和开发。在这里，我们报告了两性离子硅氧烷聚合物纳米颗粒涂层，其将颗粒的浓缩溶液的粘度降低了5倍，将注射颗粒的组织保留降低了10倍，并且重要的是，没有诱导肾脏的病理反应。
Tantalum oxide nanoparticles show great potential as the next generation of X-ray contrast media. Recently, we reported advances in tantalum oxide nanoparticles and identified improvements that were required for such particles to progress further. Namely, the viscosity of concentrated particles, the amount of retention in reticuloendothelial (RES) tissues, and the effect of large quantities of particles on the kidneys after administration were all identified as critical factors which needed further study, understanding, and development. Here, we report on a zwitterionic siloxane polymer nanopartide coating that reduced the viscosity of concentrated solutions of particles by a factor of 5, decreased tissue retention of Injected particles by a factor of 10, and, importantly, did not induce pathological responses in the kidneys.