Localization of 3H-prazosin binding sites in the supraoptic and paraventricular nuclei of the human hypothalamus.
Localization of 3H-prazosin binding sites in the supraoptic and paraventricular nuclei of the human hypothalamus.
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人下丘脑视上核和室旁核中 3H-哌唑嗪结合位点的定位。
DOI：
10.1159/000125355
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发表时间：
1990
影响因子：
4.1
通讯作者：
Dorsa,DM
中科院分区：
文献类型：
--
作者：
Wilcox,BJ;Raskind,MA;Ko,GN;Baskin,DG;Pascualy,M;Dorsa,DM
利用3h -prazosin，我们研究了α1-肾上腺素能受体在人类下丘脑视上核和室旁核中的分布。我们的研究表明，3h -prazosin在人类下丘脑的结合位点具有与大鼠脑相似的药理学特征。放射自显像研究显示3h -prazosin在室旁核和视上核的离散定位。
Using3H-prazosin, we have examined the distribution of α1-adrenergic receptors in the supraoptic and paraventricular nuclei of the human hypothalamus. Our studies show that binding sites for3H-prazosin in human hypothalamus possess pharmacological characteristics similar to those of rat brain. Autoradiographic studies revealed discrete localization of3H-prazosin to the paraventricular and supraoptic nuclei.