Additive effects of elevated C-reactive protein and exposure to Herpes Simplex Virus type 1 on cognitive impairment in individuals with schizophrenia
Additive effects of elevated C-reactive protein and exposure to Herpes Simplex Virus type 1 on cognitive impairment in individuals with schizophrenia
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DOI：
10.1016/j.schres.2011.10.003
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发表时间：
2012-01-01
影响因子：
4.5
通讯作者：
Yolken, Robert
中科院分区：
文献类型：
--
作者：
Dickerson, Faith;Stallings, Cassie;Yolken, Robert
目的：我们研究了 C 反应蛋白 (CRP) 水平升高和接触 1 型单纯疱疹病毒 (HSV-1) 对精神分裂症患者认知障碍严重程度的影响。方法：我们通过酶免疫分析检测了 588 名精神分裂症患者血清样本中 CRP 和 HSV-1 抗体的水平。使用神经心理状态评估可重复电池（RBANS）测量认知功能，使用阳性和阴性综合征量表（PANSS）测量精神症状。通过调整人口和临床变量的线性和逻辑回归分析，分析 HSV1 和 CRP 对认知功能的影响。结果：CRP 水平升高和 HSV-1 血清阳性的个体 RBANS 认知评分较低。在同时具有 HSV-1 暴露血清学证据和 CRP 水平升高的个体中发现了最强的效果。这些人的 RBANS 总分 0.5) 的几率为 2.35。结论：CRP 水平升高和接触 HSV-1 与精神分裂症认知障碍的严重程度相关。这些发现表明，感染和炎症可能在与精神分裂症相关的认知缺陷中发挥重要作用。 (C) 2011 Elsevier B.V. 保留所有权利。
Objectives: We investigated the effect of elevated levels of C-reactive protein (CRP) and exposure to Herpes simplex virus type 1 (HSV-1) on the severity of cognitive impairment in individuals with schizophrenia.Methods: We measured the levels of CRP and of antibodies to HSV-1 in serum samples from 588 individuals with schizophrenia by enzyme immunoassay tests. Cognitive functioning was measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and psychiatric symptoms with the Positive and Negative Syndrome Scale (PANSS). The effects of HSV1 and CRP on cognitive functioning were analyzed with linear and logistic regression analyses adjusting for demographic and clinical variables.Results: The individuals with elevated CRP levels and HSV-1 seropositivity had lower RBANS cognitive scores. The strongest effect was found in individuals who had both serological evidence of HSV-1 exposure and elevated levels of CRP. These individuals had odds of 2.35 to have an RBANS Total score .5).Conclusions: Elevated levels of CRP and exposure to HSV-1 are associated with the severity of cognitive impairment in schizophrenia. These findings indicate that infection and inflammation may play a major role in the cognitive deficits associated with schizophrenia. (C) 2011 Elsevier B.V. All rights reserved.