Metallothionein 1: A New Spotlight on Inflammatory Diseases.
Metallothionein 1: A New Spotlight on Inflammatory Diseases.
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DOI：
10.3389/fimmu.2021.739918
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ye L
中科院分区：
文献类型：
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作者：
Dai H;Wang L;Li L;Huang Z;Ye L
MT1已被证明是维持生理平衡和调节免疫稳态的重要应激蛋白。虽然 MT1 在中枢神经系统疾病和癌症中的免疫参与已被广泛研究，但越来越多的证据表明 MT1 在炎症性疾病中具有更广泛的作用，并且可以塑造先天性和适应性免疫。在这篇综述中，我们首先总结MT1的生物学特征以及影响MT1表达的调控因子，重点介绍金属、炎症和免疫抑制因子。接下来我们将重点关注MT1对多种免疫细胞的免疫调节功能以及MT1调控的信号通路。最后，我们将讨论 MT1 在几种炎症性疾病中生物学作用的最新进展，以开发新的治疗策略。
MT1 has been demonstrated to be an essential stress protein in maintaining physiological balance and regulating immune homeostasis. While the immunological involvement of MT1 in central nervous system disorders and cancer has been extensively investigated, mounting evidence suggests that MT1 has a broader role in inflammatory diseases and can shape innate and adaptive immunity. In this review, we will first summarize the biological features of MT1 and the regulators that influence MT1 expression, emphasizing metal, inflammation, and immunosuppressive factors. We will then focus on the immunoregulatory function of MT1 on diverse immune cells and the signaling pathways regulated by MT1. Finally, we will discuss recent advances in our knowledge of the biological role of MT1 in several inflammatory diseases to develop novel therapeutic strategies.
影响因子：
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作者：
Grubić-Kezele T;Blagojević Zagorac G;Jakovac H;Domitrović R;Milin C;Radošević-Stašić B
通讯作者：
Radošević-Stašić B