DEVELOPMENTAL PATTERN OF MUSCLE-FIBER TYPES IN HUMAN VENTILATORY MUSCLES
DEVELOPMENTAL PATTERN OF MUSCLE-FIBER TYPES IN HUMAN VENTILATORY MUSCLES
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DOI：
10.1152/jappl.1978.44.6.909
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发表时间：
1978-01-01
影响因子：
3.3
通讯作者：
IANUZZO, CD
中科院分区：
文献类型：
--
作者：
KEENS, TG;BRYAN, AC;IANUZZO, CD
早产儿对呼吸负荷耐受性差。这可能反映了骨骼肌（VM）的不完全发育，导致对疲劳的抵抗力差。为研究人膈肌畸形的发育规律，对31例膈肌和肋间肌进行了解剖学观察。使用肌原纤维（M）ATP酶（pH 10.30）和NADH四唑还原酶的组织化学染色方法，将单个肌纤维分为I型（慢收缩，高氧化）或II型（快收缩，低氧化）。在膈中，早产儿（< 37周妊娠）仅为9.7 ±。1.3%的I型纤维，足月新生儿25.0 .+-。1.1%，老年受试者（> 2岁）为54.9 ±。百分之一点三8个月后没有进一步增加。产后在肋间肌，早产儿只有19.0 .+-。4.8%的I型纤维，足月新生儿45.7 .+-。1.3%，老年受试者为65.2 .+-。百分之二点六2个月后没有进一步增加。产后新生儿的腹肌明显比老年人更容易疲劳。这可能对新生儿的呼吸问题有重大影响。
Premature infants tolerate respiratory loads poorly. This may reflect incomplete development of the ventilatory muscles (VM) causing poor resistance to fatigue. To study the developmental pattern of human VM, 31 postmortem specimens of diaphragm and intercostal muscles were obtained. Individual muscle fibers were classified as type I (slow-twitch, high-oxidative) or type II (fast-twitch, low-oxidative) using histochemical staining methods for myofibrillar (M)ATPase (pH 10.30) and NADH tetrazolium reductase. In the diaphragm, premature infants (< 37 wk gestation) had only 9.7 .+-. 1.3% type I fibers, full-term newborns 25.0 .+-. 1.1%, and older subjects (> 2 yr of age) 54.9 .+-. 1.3%. There was no further increase after 8 mo. postpartum. In the intercostal muscles, premature infants had only 19.0 .+-. 4.8% type I fibers, full-term newborns 45.7 .+-. 1.3%, and older subjects 65.2 .+-. 2.6%. There was no further increase after 2 mo. postpartum. The ventilatory muscles of newborn infants are apparently more susceptible to fatigue than those of older subjects. This may contribute significantly to respiratory problems in the neonate.