REGULATION OF INSULIN-LIKE GROWTH FACTOR-I AND GROWTH-HORMONE RECEPTOR GENE-EXPRESSION BY DIABETES AND NUTRITIONAL STATE IN RAT-TISSUES
REGULATION OF INSULIN-LIKE GROWTH FACTOR-I AND GROWTH-HORMONE RECEPTOR GENE-EXPRESSION BY DIABETES AND NUTRITIONAL STATE IN RAT-TISSUES
复制标题
DOI：
10.1677/joe.0.1220651
复制
发表时间：
1989-09-01
影响因子：
4
通讯作者：
NORSTEDT, G
中科院分区：
文献类型：
--
作者：
BORNFELDT, KE;ARNQVIST, HJ;NORSTEDT, G
胰岛素样生长因子-I（IGF-I）mRNA和GH受体mRNA的水平进行了分析，在不同的组织中，从大鼠糖尿病与链脲佐菌素，禁食大鼠和大鼠喂养的蛋白质减少的饮食。糖尿病降低了肝脏、心脏、膈肌、肾脏和主动脉中IGF-I mRNA的水平，但在脑中没有。GH受体mRNA水平在心脏和膈肌中降低，但在肝脏和肾脏中没有。空腹降低IGF-I mRNA在所有组织中的研究，除了大脑，并降低GH受体mRNA在肝脏，心脏和膈肌，但不是在肾脏。蛋白质减少的饮食降低肝脏IGF-I mRNA水平，但没有显着影响其他组织，而GH受体mRNA水平降低肝脏和膈肌。总之，糖尿病和营养不足影响IGF-I和GH受体mRNA在不同的组织，但这两种mRNA并没有协调调节在所有组织研究。虽然GH受体基因表达降低可能是某些状态和组织中IGF-I基因表达降低的原因，但其他调节机制可能很重要。
Insulin-like growth factor-I (IGF-I) mRNA and GH receptor mRNA levels were analysed in different tissues from rats made diabetic with streptozotocin, fasted rats and rats fed with a protein-reduced diet. Diabetes decreased IGF-I mRNA levels in liver, heart, diaphragm, kidney and aorta, but not in brain. GH receptor mRNA levels were decreased in heart and diaphragm, but not in liver and kidney. Fasting decreased IGF-I mRNA in all tissues studied except brain, and decreased GH receptor mRNA in liver, heart and diaphragm, but not in kidney. A protein-reduced diet decreased hepatic IGF-I mRNA levels but did not significantly affect other tissues, while GH receptor mRNA levels were reduced in liver and diaphragm. In conclusion, both diabetes and limited nutrition affected IGF-I and GH receptor mRNA in different tissues, but the two mRNAs were not co-ordinately regulated in all tissues studied. While reduced GH receptor gene expression may thus be responsible for decreased IGF-I gene expression in some states and tissues, additional regulatory mechanisms may be of importance.