Bone mineral acquisition during adolescence and early adulthood: A study in 574 healthy females 10-24 years of age
Bone mineral acquisition during adolescence and early adulthood: A study in 574 healthy females 10-24 years of age
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DOI：
10.1007/bf01623938
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发表时间：
1996-01-01
影响因子：
4
通讯作者：
Denis, AY
中科院分区：
文献类型：
--
作者：
Sabatier, JP;GuaydierSouquieres, G;Denis, AY
众所周知，低骨量与骨折风险增加有关。通过最大限度地增加骨量来预防骨质疏松症将是至关重要的，需要更好地了解青春期骨量的获得。在574名10-24岁的健康女性志愿者中评估了骨量。采用双能X线骨密度仪（DXA）测量前后位（AP L2-4）和侧位（LAT L3）的脊柱骨密度（BMD），并计算AP骨矿含量（BMC）。同时对333名27-47岁正常育龄妇女进行了腰椎AP-BMD（L2-4）测定。骨值，骨钙素和IGF-1血清浓度与实足年龄，骨龄，青春期阶段和初潮后的时间。在这项横断面研究中，AP和LAT-BMD和BMC在骨龄10至14之间或直到初潮后第一年急剧增加。在14至17骨龄之间，AP-BMD和BMC适度增加，而LAT-BMD保持不变。骨龄17岁后，或初潮后第4年，BMD或BMC没有显著增加，其值与绝经期妇女没有差异。血清骨钙素峰值出现在骨龄11-12或P3阶段，而IGF-1峰值出现在骨龄13-14或P3和初潮后第一年。86%的成年人脊柱骨量是在骨龄14岁之前或月经初潮后第二年获得的;因此，骨质疏松症预防计划在该年龄之前特别有效。
Low bone mass is known to be associated with an increased risk of fractures. Osteoporosis prevention by maximizing bone mass will be crucial and requires a better knowledge of bone mass acqusition during adolescence. Bone mass was assessed in 574 healthy volunteer females aged 10-24 years. Spine bone mineral density (BMD) in anteroposterior (AP L2-4) and lateral (LAT L3) views was measured using dual-energy X-ray absorptiometry (DXA) and AP bone mineral content (BMC) was calculated. At the same time, spine AP-BMD (L2-4) was evaluated in 333 normal menstruating women, aged 27-47 years. Bone values, osteocalcin and IGF-1 serum concentrations were correlated with chronological age, skeletal age, pubertal stages and time after menarche. In this cross-sectional study, AP-and LAT-BMD and BMC increased dramatically between skeletal ages 10 and 14 or until the first year after menarche. Between 14 and 17 skeletal years of age, AP-BMD and BMC increased moderately, whereas LAT-BMD remained unchanged. After skeletal age 17, or the fourth year after menarche, there was no significant increase in BMD or BMC, and their values did not differ from those of menstruating women. A serum osteocalcin peak was observed at skeletal ages 11-12 or at stage P3, whereas IGF-1 peaked at 13-14 skeletal years of age or at P3 and the first year after menarche. Eighty-six per cent of the adult bone mass of the spine is acquired before skeletal age 14 or the secund year after menarche; therefore osteoporosis prevention programs will be particularly effective before that age.