The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent
The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent
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DOI：
10.1210/jc.2004-0981
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发表时间：
2004-12-01
影响因子：
5.8
通讯作者：
Wüst, S
中科院分区：
文献类型：
--
作者：
Federenko, IS;Nagamine, M;Wüst, S
下丘脑-垂体-肾上腺轴对压力反应的个体差异在健康和疾病风险中起着重要作用。这些个体差异的起源或决定因素还没有得到很好的理解。到目前为止，还没有研究检查的影响，环境的遗传性的心理内分泌应激反应。在本研究中，58对男性双胞胎暴露于心理社会压力（特里尔社会压力测试）每周三次，和他们的唾液和总皮质醇，促肾上腺皮质激素和心率反应进行了评估。在第一次应激暴露时，观察到所有测量值的适度遗传力（所有h（2）< 0.33），但随着应激源的重复，遗传力估计值大幅增加（T3：所有h（2）> 0.97）。同时，只有第一次而不是第二次和第三次Trier社会压力测试暴露引起了状态焦虑的显著增加（T1：P < 0.01，T2和T3：n.s.），这表明在一个新的、引起焦虑的环境中遗传性较低，而在一个熟悉的、低焦虑的环境中遗传性较高。这些研究结果挑战了以前的报告，刺激下丘脑垂体肾上腺轴活动的标记物的遗传性低，是第一个记录的背景下的精神内分泌遗传性估计的相关性。
Individual differences in the response of the hypothalamus pituitary adrenal axis to stress are known to play an important role in health and disease risk. The origins, or determinants, of these individual differences are not well understood. To date, no study has examined the effects of context on the heritability of psychoendocrine stress responses. In the present study, 58 male twin pairs were exposed to a psychosocial stressor ( Trier Social Stress Test) three times at weekly intervals, and their salivary and total cortisol, ACTH, and heart rate responses were assessed. Modest heritabilities were observed for all measures at the first stress exposure (all h(2) < 0.33), but heritability estimates increased substantially with repetition of the stressor (T3: all h(2) > 0.97). Concurrently, only the first but not the second and third Trier Social Stress Test exposure induced a significant increase in state anxiety (T1: P < 0.01, T2 and T3: n.s.), suggesting low heritabilities in a new, anxiety-evoking context and high heritabilities in a familiar, low-anxiety context. These findings challenge previous reports on a low heritability of markers of stimulated hypothalamus pituitary adrenal axis activity and are the first to document the relevance of context for psychoendocrine heritability estimates.