Effect of sinoaortic denervation on pressor responses in pregnant rats.
Effect of sinoaortic denervation on pressor responses in pregnant rats.
复制标题
去窦主动脉神经对妊娠大鼠升压反应的影响。
DOI：
10.1152/ajpregu.1992.262.6.r1100
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Barron,WM
中科院分区：
文献类型：
--
作者：
Hines,T;Barron,WM
我们测试的假设，增强动脉压力感受性反射活动有助于衰减的升压反应在完整的妊娠动物比较血压和心率的变化，血管紧张素II，苯肾上腺素，加压素在长期仪表怀孕和处女大鼠约5周后，窦弓神经切断术（SAD）或假手术。在假手术（妊娠91.7 +/- 1.7 mmHg，处女103.7 +/- 2.5 mmHg）和SAD状态（妊娠107.3 +/- 4.0 mmHg，处女114.1 +/- 4.0 mmHg）下，妊娠动物的基线平均动脉压均显着较低。加压反应，所有三个代理人显着钝化在怀孕的动物相比，类似的处理处女，衰减的幅度相似，在假手术和SAD状态。心率下降类似反射完整的怀孕和处女动物在加压输液。这些研究结果表明，衰减的升压反应在怀孕大鼠主要是由于动脉压力感受性反射活动的增强以外的机制，并与妊娠期间血管敏感性的普遍降低一致。
We tested the hypothesis that augmented arterial baroreflex activity contributes to attenuation of pressor responses in intact pregnant animals by comparing changes in blood pressure and heart rate during infusions of angiotensin II, phenylephrine, and vasopressin in chronically instrumented pregnant and virgin rats approximately 5 wk after sinoaortic denervation (SAD) or sham surgery. Baseline mean arterial pressure was significantly lower in pregnant animals in both the sham-operated (pregnant 91.7 +/- 1.7 mmHg, virgin 103.7 +/- 2.5 mmHg) and SAD states (pregnant 107.3 +/- 4.0 mmHg, virgin 114.1 +/- 4.0 mmHg). Pressor responses to all three agents were significantly blunted in pregnant animals compared with similarly treated virgins, with the magnitude of attenuation similar in both sham and SAD states. Heart rate decreased similarly in reflex-intact pregnant and virgin animals during pressor infusions. These findings suggest that attenuated pressor responses in the pregnant rat are due primarily to mechanisms other than augmentation of arterial baroreflex activity and are consistent with a generalized reduction in vascular sensitivity during gestation.