Altered fecal microbiota composition in patients with major depressive disorder
Altered fecal microbiota composition in patients with major depressive disorder
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DOI：
10.1016/j.bbi.2015.03.016
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发表时间：
2015-08-01
影响因子：
15.1
通讯作者：
Ruan, Bing
中科院分区：
文献类型：
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作者：
Jiang, Haiyin;Ling, Zongxin;Ruan, Bing
使用动物模型的研究表明，抑郁症会影响微生物群的稳定性，但重度抑郁症（MDD）患者的实际结构和组成尚不清楚。在这里，我们分析了46例抑郁症患者（29例活动型MDD和17例应答型MDD）和30例健康对照（HC）的粪便样本。高通量焦磷酸测序显示，根据香农指数，在活性MDD（A-MDD）与HC组中发现粪便细菌α多样性增加，但在应答MDD（R-MDD）与HC组中未发现。拟杆菌门、变形菌门和放线菌门的水平显著增加，而厚壁菌门的水平在A-MDD和R-MDD组中与HC组相比显著降低。尽管存在深刻的个体间变异，但MDD组和HC组之间的几个主要属的水平存在显著差异。最值得注意的是，MDD组的肠杆菌科和Alistipes水平增加，但粪杆菌水平降低。粪杆菌与抑郁症状的严重程度呈负相关。这些发现使我们能够更好地了解这些患者粪便微生物群组成的变化，显示出一些潜在有害细菌群的优势或有益细菌属的减少。进一步的研究是必要的，以阐明肠道微生物群和抑郁症之间的时间和因果关系，并评估微生物群作为生物标志物的适用性。(C)2015年，作者。爱思唯尔公司出版
Studies using animal models have shown that depression affects the stability of the microbiota, but the actual structure and composition in patients with major depressive disorder (MDD) are not well understood. Here, we analyzed fecal samples from 46 patients with depression (29 active-MDD and 17 responded-MDD) and 30 healthy controls (HCs). High-throughput pyrosequencing showed that, according to the Shannon index, increased fecal bacterial alpha-diversity was found in the active-MDD (A-MDD) vs. the HC group but not in the responded-MDD (R-MDD) vs. the HC group. Bacteroidetes, Proteobacteria, and Actinobacteria strongly increased in level, whereas that of Firmicutes was significantly reduced in the A-MDD and R-MDD groups compared with the HC group. Despite profound interindividual variability, levels of several predominant genera were significantly different between the MDD and HC groups. Most notably, the MDD groups had increased levels of Enterobacteriaceae and Alistipes but reduced levels of Faecalibacterium. A negative correlation was observed between Faecalibacterium and the severity of depressive symptoms. These findings enable a better understanding of changes in the fecal microbiota composition in such patients, showing either a predominance of some potentially harmful bacterial groups or a reduction in beneficial bacterial genera. Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and depression and to evaluate the suitability of the microbiome as a biomarker. (C) 2015 The Authors. Published by Elsevier Inc.