A neural network for intermale aggression to establish social hierarchy
A neural network for intermale aggression to establish social hierarchy
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DOI：
10.1038/s41593-018-0153-x
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发表时间：
2018-06-01
影响因子：
25
通讯作者：
Broberger, Christian
中科院分区：
文献类型：
--
作者：
Stagkourakis, Stefanos;Spigolon, Giada;Broberger, Christian
男性间的攻击被用来建立社会等级。一些神经元群体与攻击行为有关，但塑造这种先天行为并协调其不同组成部分（包括攻击执行和奖励）的回路机制仍然难以捉摸。我们发现，下丘脑腹侧前乳头核中表达多巴胺转运蛋白的神经元（PMv（DAT）神经元）在雄性小鼠中组织目标导向的攻击行为。 PMv(DAT)神经元的激活触发攻击行为；沉默这些神经元会中断攻击。再生 PMv(DAT) 膜电导与反复和相互激励的相互作用解释了短暂的触发如何引起持久的响应（滞后）。 PMv（DAT）对腹内侧下丘脑腹外侧部分和乳头上核的预测分别控制攻击执行和攻击奖励。对 PMv(DAT) 活性的短暂控制改变了雄性之间的优势关系，这种效应持续数周。这些结果确定了锚定在 PMv(DAT) 神经元中的网络结构，该结构组织攻击性行为，从而决定男性间的等级制度。
Intermale aggression is used to establish social rank. Several neuronal populations have been implicated in aggression, but the circuit mechanisms that shape this innate behavior and coordinate its different components (including attack execution and reward) remain elusive. We show that dopamine transporter-expressing neurons in the hypothalamic ventral premammillary nucleus (PMv(DAT) neurons) organize goal-oriented aggression in male mice. Activation of PMv(DAT) neurons triggers attack behavior; silencing these neurons interrupts attacks. Regenerative PMv(DAT) membrane conductances interacting with recurrent and reciprocal excitation explain how a brief trigger can elicit a long-lasting response (hysteresis). PMv(DAT) projections to the ventrolateral part of the ventromedial hypothalamic and the supramammillary nuclei control attack execution and aggression reward, respectively. Brief manipulation of PMv(DAT) activity switched the dominance relationship between males, an effect persisting for weeks. These results identify a network structure anchored in PMv(DAT) neurons that organizes aggressive behavior and, as a consequence, determines intermale hierarchy.