Membrane-less compartments in the nucleus: Separated or connected phases?
Membrane-less compartments in the nucleus: Separated or connected phases?
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DOI：
10.1016/j.ceb.2023.102215
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发表时间：
2023-08-11
影响因子：
7.5
通讯作者：
Cai，Danfeng
中科院分区：
文献类型：
--
作者：
Liang，Jindayi;Cai，Danfeng
近年来，越来越清楚的是，许多无核膜区室具有液体样性质，并可能通过相分离的物理化学过程形成。在这篇综述中，我们将首先讨论各种核隔间，如基因组，转录隔间和核体是如何通过相分离形成的。然后，我们提出，间室通信也可以是普遍的，并可能介导的大分子间室扩散，不同的车厢之间的融合，以及核车厢之间的短暂或稳定的接触。了解核区室如何相互通信是一个令人兴奋的新研究领域，可能揭示有关细胞功能的重要见解，并揭示以前未被充分认识的疾病机制。
In recent years, it has become increasingly clear that many nuclear membrane-less compartments have liquid-like properties and may form through the physicochemical process of phase separation. In this review, we will first discuss how various nuclear compartments, such as the genome, transcription compartments, and nuclear bodies are formed through phase separation. Then, we propose that inter-compartmental communications can also be prevalent and may be mediated by inter-compartmental diffusion of macromolecules, fusion among different compartments, and transient or stable contacts among nuclear compartments. Understanding how nuclear compartments communicate with each other represents an exciting new area of research and may reveal important insights about cellular functions and uncover previously under-appreciated disease mechanisms.