Effects of dog ownership and genotype on immune development and atopy in infancy
Effects of dog ownership and genotype on immune development and atopy in infancy
复制标题
DOI：
10.1016/j.jaci.2003.11.017
复制
发表时间：
2004-02-01
影响因子：
14.2
通讯作者：
Lemanske, RF
中科院分区：
文献类型：
--
作者：
Gern, JE;Reardon, CL;Lemanske, RF
背景资料：暴露于毛皮宠物可能会通过一种机制，这是不完全understood.Objective：本研究的目的是确定宠物暴露和基因型对免疫发育和发病率的特应性标志物和疾病的第一年的生活中的影响，对过敏性致敏的发展提供保护。研究方法：在285名婴儿中，将家中的宠物暴露与细胞因子分泌模式（出生时和1岁时的有丝分裂原刺激的单核细胞）和特应性指标（过敏原特异性和总IgE、嗜酸性粒细胞增多症、食物过敏、特应性皮炎）进行了比较。在数据analysis.Results：暴露于狗与减少过敏原致敏（19%比33%，P = 0.020）和特应性皮炎（30%比51%，P <0.001）的基因型的相互作用也进行了评估。特应性皮炎的风险进一步受到CD 14基因座基因型的影响（P = 0.006），即使在调整了对狗的暴露后（P = 0.003）。此外，基因型为-159TT的婴儿如果接触狗，患特应性皮炎的可能性较小（5% vs 43%，P = 0.04）。最后，狗暴露与1岁时IL-10（117 vs 79 pg/mL，P =.002）和IL-13（280 vs 226 pg/mL，P =.013）反应的增加相关。结论：婴儿期养狗与较高的IL-10和IL-13细胞因子分泌谱和降低过敏性致敏性和特应性皮炎相关。这些研究结果表明，出生后暴露于狗可以影响免疫发育的基因型特异性的方式，从而减弱特应性的发展在高危儿童。
Background: Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood.Objective: The objective of this study was to determine the effects of pet exposure and genotype on immunologic development and the incidence of atopic markers and diseases in the first year of life. Methods: Pet exposure in the home was compared with cytokine secretion patterns (mitogen-stimulated mononuclear cells at birth and age 1 year) and indicators of atopy (allergen-specific and total IgE, eosinophilia, food allergy, atopic dermatitis) in 285 infants. Interactions with genotype at the CD14 locus were also evaluated in the data analyses.Results: Exposure to dogs was associated with reduced allergen sensitization (19% vs 33%, P =.020) and atopic dermatitis (30% vs 51%, P < .001). The risk for atopic dermatitis was further influenced by genotype at the CD14 locus (P =.006), even after adjusting for exposure to dogs (P =.003). Furthermore, infants with the genotype -159TT were less likely to develop atopic dermatitis if they were exposed to a dog (5% vs 43%, P =.04). Last, dog exposure was associated with increased IL-10 (117 vs 79 pg/mL, P =.002) and IL-13 (280 vs 226 pg/mL, P =.013) responses at age 1 year.Conclusions: Having a dog in infancy is associated with higher IL-10 and IL-13 cytokine secretion profiles and reduced allergic sensitization and atopic dermatitis. These findings suggest that postnatal exposure to dogs can influence immune development in a genotype-specific fashion and thereby attenuate the development of atopy in at-risk children.