In vivo demonstration of ultrasound power delivery to charge implanted medical devices via acute and survival porcine studies.
In vivo demonstration of ultrasound power delivery to charge implanted medical devices via acute and survival porcine studies.
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DOI：
10.1016/j.ultras.2015.07.012
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发表时间：
2016-01
期刊：
影响因子：
4.2
通讯作者：
Makin IR
中科院分区：
文献类型：
--
作者：
Radziemski L;Makin IR
动物研究是证明基于超声波的植入式电池充电系统的实用性和安全性的重要一步。为此，开发并测试了超声波充电系统 (USER™)。体外实验证明，电池可通过 10 – 15 毫米的组织提供高达 600 mW 的功率，在组织深度达 50 mm 时可提供 50 mW 的功率，以及使用与钛粘合的传感器用于医疗植入物的可行性。猪模型的急性体内研究用于测试电力输送、温度偏移和冷却技术的可靠性。最终的五周生存研究涉及重复电池充电，对介入的活体组织进行总共 10.5 小时的超声波照射，平均射频输入充电效率为 20%。这项研究可能是第一个使用经皮超声功率传输到原位植入接收器的长期累积活组织暴露研究。暴露组织的组织学显示变化主要归因于原型装置的手术植入，并且没有由于超声暴露而造成损伤。体内结果表明，在一组定义的源条件下，可以安全地输送超声能量，以便为植入物内的电池充电。
Animal studies are an important step in proving the utility and safety of an ultrasound based implanted battery recharging system. To this end an Ultrasound Electrical Recharging System (USER™) was developed and tested. Experiments in vitro demonstrated power deliveries at the battery of up to 600 mW through 10 – 15 mm of tissue, 50 mW of power available at tissue depths of up to 50 mm, and the feasibility of using transducers bonded to titanium as used in medical implants. Acute in vivo studies in a porcine model were used to test reliability of power delivery, temperature excursions, and cooling techniques. The culminating five-week survival study involved repeated battery charging, a total of 10.5 hours of ultrasound exposure of the intervening living tissue, with an average RF input to electrical charging efficiency of 20%. This study was potentially the first long term cumulative living-tissue exposure using transcutaneous ultrasound power transmission to an implanted receiver in situ. Histology of the exposed tissue showed changes attributable primarily due to surgical implantation of the prototype device, and no damage due to the ultrasound exposure. The in vivo results are indicative of the potential safe delivery of ultrasound energy for a defined set of source conditions for charging batteries within implants.