H2A.Z: view from the top.
H2A.Z: view from the top.
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DOI：
10.1016/j.str.2007.12.008
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发表时间：
2008-02
期刊：
影响因子：
5.7
通讯作者：
J. Zlatanova;A. Thakar
中科院分区：
文献类型：
--
作者：
J. Zlatanova;A. Thakar
几十年来，染色质领域一直受到不应有的忽视。事实上，一个单调的重复结构，其生命的目的是包装DNA，这有什么令人兴奋的呢？由于人们认识到染色质在基因表达和其他发生在DNA模板上的核过程的调节中起着重要作用，染色质的魅力又胜利地回来了。调节转录的结构的动力学本身受到各种复杂过程的调节，包括组蛋白合成后修饰、染色质重塑和非等位基因组蛋白变体的使用。这篇综述试图了解进化上保守的变体H2A.Z的作用机制，该变体具有各种看似无关，甚至相反的功能。这一尝试是由最近雪崩的全基因组研究所推动的，这些研究提供了直到最近都无法想象的见解。
For a couple of decades the chromatin field has endured undeserved neglect. Indeed, what could be so exciting about a monotonous repeating structure whose purpose in life was to package DNA? Chromatin glamour is triumphantly back, due to the realization that chromatin is a major player in the regulation of gene expression and other nuclear processes that occur on the DNA template. The dynamics of the structure that regulates transcription is itself regulated by a variety of complex processes, including histone postsynthetic modifications, chromatin remodeling, and the use of nonallelic histone variants. This review is an attempt to understand the mechanisms of action of the evolutionarily conserved variant H2A.Z, a player with a variety of seemingly unrelated, even contrary, functions. This attempt was prompted by the recent avalanche of genome-wide studies that provide insights that were unthinkable until very recently.