Asbestos Surveillance Program Aachen (ASPA):: initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT
Asbestos Surveillance Program Aachen (ASPA):: initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT
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DOI：
10.1007/s00330-006-0426-8
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发表时间：
2007-05-01
影响因子：
5.9
通讯作者：
Wildberger, Joachim E.
中科院分区：
文献类型：
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作者：
Das, Marco;Muehlenbruch, Georg;Wildberger, Joachim E.
本研究的目的是使用低剂量MDCT评估高风险石棉暴露队列中肺癌的患病率。在5389名前电厂工作人员中，根据包括年龄、接触石棉和吸烟习惯在内的肺癌风险模型，316人被列为肺癌风险最高的个体。在这316人中，187人（平均年龄：66.6岁）被纳入前瞻性试验。平均石棉暴露时间为29.65年，89%为吸烟者。在16排MDCT （Siemens）上进行低剂量筛选（10/20 ma (eff)）；1 mm/0.5 mm增量)。除了软拷贝PACS读数分析外，还在工作站使用专用肺分析软件（LungCARE; Siemens）进行分析。强烈可疑肿块1例，组织学证实肺癌8例，肺结节491个，平均体积40.72 ml，平均直径4.62 mm。80人可见石棉相关改变（胸膜斑块、纤维化）。该高危队列的肺癌筛查显示，基线筛查时肺癌患病率为4.28%(8/187)，另外还有大量不确定的肺结节。低剂量多层螺旋ct在这一高度选择性人群中被证明是可行的。
The purpose of this study was to assess the prevalence of lung cancer in a high-risk asbestos-exposed cohort using low-dose MDCT. Of a population of 5,389 former power-plant workers, 316 were characterized as individuals at highest risk for lung cancer according to a lung-cancer risk model including age, asbestos exposure and smoking habits. Of these 316, 187 (mean age: 66.6 years) individuals were included in a prospective trial. Mean asbestos exposure time was 29.65 years and 89% were smokers. Screening was performed on a 16-slice MDCT (Siemens) with low-dose technique (10/20 mAs(eff.); 1 mm/0.5 mm increment). In addition to soft copy PACS reading analysis on a workstation with a dedicated lung analysis software (LungCARE; Siemens) was performed. One strongly suspicious mass and eight cases of histologically proven lung cancer were found plus 491 additional pulmonary nodules (average volume: 40.72 ml, average diameter 4.62 mm). Asbestos-related changes (pleural plaques, fibrosis) were visible in 80 individuals. Lung cancer screening in this high-risk cohort showed a prevalence of lung cancer of 4.28% (8/187) at baseline screening with an additional large number of indeterminate pulmonary nodules. Low-dose MDCT proved to be feasible in this highly selected population.