Gene therapy for HCV/HBV-induced hepatocellular carcinoma.
Gene therapy for HCV/HBV-induced hepatocellular carcinoma.
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发表时间：
2010-12
影响因子：
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通讯作者：
C. Smerdou;S. Menne;R. Hernández-Alcoceba;G. González-Aseguinolaza
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作者：
C. Smerdou;S. Menne;R. Hernández-Alcoceba;G. González-Aseguinolaza
HBV和HCV感染被认为是肝细胞癌（HCC）最重要的病因。目前的治疗方案不足，迫切需要新的治疗策略来抑制疾病进展并提高HCC患者的生存率。治疗HCC的一个很有前景的策略是基因治疗（GT），其特点是肿瘤细胞转导具有抗肿瘤特性的基因，如促凋亡、自杀、抗血管生成和免疫调节基因，以及sirna。其他的GT策略已经研究了溶瘤病毒载体，它们在肿瘤细胞中特异性繁殖，随后杀死这些恶性细胞。此外，旨在阻止病毒增殖的GT策略，如基因疫苗或对病毒复制的遗传干扰，以及防止病毒诱导的致癌前变化的策略，代表了预防HCC发展的最有效策略。这些GT方法有望替代、补充或替代目前HCC的治疗方案。本文综述了近十年来肝细胞癌的发展趋势，包括在动物模型和患者中的研究，以预防和治疗肝炎病毒诱导的肝细胞癌。
Infection with HBV and HCV are considered the most important etiological factors for hepatocellular carcinoma (HCC). Current treatment options are insufficient, creating an urgent need for new therapeutic strategies that inhibit disease progression and improve survival in patients with HCC. A promising strategy for the treatment of HCC is gene therapy (GT), which is characterized by the transduction of tumor cells with genes displaying antitumor properties, such as pro-apoptotic, suicide, anti-angiogenic and immunomodulatory genes, as well as siRNAs. Other GT strategies have investigated oncolytic viral vectors that propagate specifically in tumor cells and, subsequently, kill these malignant cells. Furthermore, GT strategies directed toward halting virus proliferation, such as genetic vaccines or genetic interference with viral replication, as well as strategies that prevent viral induced pre-carcinogenic changes, represent the most efficient strategies to prevent HCC development. These GT approaches are promising alternatives to, and could complement or substitute, current treatment options for HCC. This review summarizes trends in GT during the past decade, including investigations in animal models and patients for the prevention and treatment of hepatitis virus-induced HCC.