Vitamin D and Parathyroid Hormone Relationships with Urinary Nitric Oxide Metabolites and Plasma Isoprostanes in African-Americans.
Vitamin D and Parathyroid Hormone Relationships with Urinary Nitric Oxide Metabolites and Plasma Isoprostanes in African-Americans.
复制标题
非洲裔美国人中维生素 D 和甲状旁腺激素与尿一氧化氮代谢物和血浆异前列烷的关系。
DOI：
10.1159/000339942
复制
发表时间：
2012
影响因子：
3.8
通讯作者：
Flack,JohnM
中科院分区：
文献类型：
--
作者：
Valiña-Tóth,AnnaLiza;Lai,Zongshan;Zhang,Shilling;Flack,JohnM
背景：维生素D缺乏和甲状旁腺激素(PTH)继发性升高在肥胖的非裔美国人中非常普遍。与白人相比，与氧化应激相关的内皮功能障碍在非裔美国人中更常见。目前，在非裔美国人中，维生素D(25-羟基维生素D，25-羟基维生素D)和甲状旁腺素与一氧化氮代谢物(NOx)-硝酸盐和亚硝酸盐-和氧化应激之间的关系尚不清楚。目的：采用横断面设计，确定25-羟基D和甲状旁腺素与超重(体重指数25-39.9)、正常血压的非裔美国人≥35岁超重(体重指数25-39.9)和正常血压的非裔美国人之间的关系。测量：调整了年龄、性别、体重指数、并用季节测定了25-羟基-D和甲状旁腺素与一氧化氮合酶和异前列腺素的关系。在对相同协变量进行调整的一般线性模型中，比较了3组相互排斥的维生素D/甲状旁腺素：(1)正常25-羟基D(51-249nmol/L)和正常甲状旁腺素(≤65pg/ml)；(2)低25-羟基D和正常甲状旁腺素，(3)低25-羟基D和高甲状旁腺素。结果：25-羟基D在甲状旁腺素水平调整前(P=0.02)和调整后(P=0.03)与NOX直接相关。甲状旁腺激素和异前列腺素之间存在明显的相关性(p=0.08)。在维生素D/PTH 1-3组中，NOX分别为424、290和270微克分子/8小时(p=0.08)。结论：在超重、血压正常的成年非裔美国人中，25-羟基D直接与无效性有关，而甲状旁腺素与异前列腺素呈正相关。
Background:Vitamin D deficiency and secondary rises in parathyroid hormone (PTH) are highly prevalent in obese African-Americans. Endothelial dysfunction related to oxidative stress is more common in African-Americans compared to whites. Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH to nitric oxide metabolites (NOx) – nitrate and nitrite – and oxidative stress in African-Americans is unknown.Objective:A cross-sectional design was utilized to determine the association of 25-OH D and PTH with urinary NOx (UNOx) (n = 101) and plasma isoprostanes (n = 125), an oxidative stress marker, in overweight (body mass index of 25–39.9), normotensive African-Americans aged ≥35 years.Measurements:Multivariable linear regression analysis adjusted for age, sex, body mass index, and season was used to determine the relationship of 25-OH D and PTH to UNOx and isoprostanes. General linear models, adjusted for the same covariates, contrasted UNOx across three mutually exclusive vitamin D/PTH groups: (1) normal 25-OH D (51–249 nmol/l) and normal PTH (≤65 pg/ml); (2) low 25-OH D and normal PTH, and (3) low 25-OH D and high PTH.Results:25-OH D was directly associated with UNOx before (p = 0.02) and after (p = 0.03) adjustment for PTH levels. A borderline significant association was observed between PTH and isoprostanes (p = 0.08). UNOx was 424, 290, and 270 µmol/8 h, respectively, across vitamin D/PTH groups 1–3 (p = 0.08).Conclusion:25-OH D was directly associated with NO availability and PTH was positively, though borderline, associated with isoprostanes in overweight, normotensive adult African-Americans.