Embryo viability and metabolism: obeying the quiet rules
Embryo viability and metabolism: obeying the quiet rules
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DOI：
10.1093/humrep/dem253
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发表时间：
2007-12-01
影响因子：
6.1
通讯作者：
McEvoy, Tom G.
中科院分区：
文献类型：
--
作者：
Leese, Henry J.;Sturmey, Roger G.;McEvoy, Tom G.
有人提出，植入前胚胎在培养过程中和胚胎移植后的活力与“安静”的新陈代谢有关。可存活的胚胎可能会更好地应对基因组、转录组和蛋白质组的损害，或者它们可能比不能存活的胚胎受到的损害更小。方法：在人和小鼠身上获得了大量关于无症状胚胎假说的数据。在这篇文章中，有证据表明，安静假说同样适用于家畜的繁殖，这可以为人类提供很好的模型。结果：数据，特别是对绵羊和奶牛的数据表明，早期胚胎发育期间的安静代谢与成功的胚胎发育是一致的。相反，“活跃”的新陈代谢与晚年的结果不太理想有关。结论：挑战是确定一个特定标记物的值范围，在这个范围内胚胎有很高的机会产生健康的后代。我们还推测了可能鼓励这种新陈代谢的方式，以及对肥胖女性受孕前减肥的影响。
It has been proposed that preimplantation embryo viability during culture and following embryo transfer is associated with a 'quiet' metabolism. Viable embryos may be better equipped to contend with damage to the genome, transcriptome and proteome, or they may possess less damage than non-viable embryos. METHODS: Much of the data for the quiet embryo hypothesis was obtained in the human and mouse. In this article, evidence is reviewed suggesting that the quiet hypothesis may equally be applied to reproduction in livestock, which can provide good models for the human. RESULTS: Data, particularly for the sheep and cow, suggest that a quiet metabolism during early embryo development is consistent with successful embryo development. Conversely, an 'active' metabolism is associated with sub-optimal outcomes in later life. CONCLUSIONS: The challenge is to identify the range of values for a given marker within which an embryo has a high chance of giving rise to healthy offspring. We also speculate on the ways in which such a metabolic profile might be encouraged and the implications for weight loss in obese women prior to conception.