Palladium-catalyzed double C-H activation: one-pot synthesis of benzo[c] pyrazolo[1,2-a]-cinnolin-1-ones from 5-pyrazolones and aryl iodides
Palladium-catalyzed double C-H activation: one-pot synthesis of benzo[c] pyrazolo[1,2-a]-cinnolin-1-ones from 5-pyrazolones and aryl iodides
复制标题
钯催化双C-H活化：由5-吡唑啉酮和芳基碘化物一锅法合成苯并[c]吡唑并[1,2-a]-cinnolin-1-ones
DOI：
10.1039/c3cc47989g
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Zhang, Ao
中科院分区：
文献类型：
--
作者：
Fan, Zhoulong;Wu, Kui;Zhang, Ao
采用钯催化的双C-H活化反应构建C-C/C-N键，一锅法合成苯并[c]吡唑并[1，2-a]-肉桂林-1-酮。这种方法包括使用吡唑啉酮部分作为C-H活化的内部导向基团，并提供了一种灵活的策略来访问这种多环骨架。
A palladium-catalyzed dual C-H activation to construct C-C/C-N bonds for one-pot synthesis of benzo[c] pyrazolo[1,2-a]-cinnolin-1-ones is successfully developed. This approach involves using a pyrazolone moiety as an internal directing group for C-H activation, and provides a flexible strategy to access this polycyclic skeleton.