The effects of the mediodorsal nucleus of the thalamus on respiratory neurons of the medulla oblongata and respiration in rats in conditions of hypoxia.
The effects of the mediodorsal nucleus of the thalamus on respiratory neurons of the medulla oblongata and respiration in rats in conditions of hypoxia.
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DOI：
10.1007/bf02463100
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发表时间：
2000-07-01
影响因子：
--
通讯作者：
Sarkisyan, N V
中科院分区：
文献类型：
--
作者：
Akopyan, N S;Baklavadzhyan, O G;Sarkisyan, N V
在正常条件下和缺氧条件下，研究了丘脑相关的背内侧核对延髓呼吸神经元放电活动和呼吸的影响。在正常的大气压下，在动物被升高到低压之前，丘脑背内侧核的电刺激具有主要的抑制作用。在缺氧的初始阶段，在4，000 - 5，000米的“高度”，发生神经元放电频率的缺氧激活。呼吸频率增加。在这些条件下，刺激丘脑背内侧核的抑制作用不如在常氧条件下显著。相反的作用发生在缺氧的第二阶段（7500 - 8000米）--延髓和丘脑中枢的活动受到抑制。在严重缺氧，有抑制神经元尖峰活动和呼吸频率的减少，这成为表面;在这些条件下，丘脑的抑制作用是微不足道的。
The effects of the associated mediodorsal nucleus of the thalamus on spike activity of respiratory neurons in the medulla oblongata and on respiration were studied in normal conditions and in oxygen insufficiency. At normal atmospheric pressure, before animals were elevated to low pressures, electrical stimulation of the mediodorsal nucleus of the thalamus had predominantly inhibitory effects. At the initial phase of hypoxia, at a "height" of 4,000-5,000 m, hypoxic activation of neuron discharge frequency occurred. with an increase in the frequency of respiration. In these conditions, the inhibitory effect of stimulation of the mediodorsal nucleus of the thalamus was less marked than in normoxic conditions. The opposite effect occurred at the second phase of hypoxia (7,500-8,000 m)-inhibition of activity in the medulla oblongata and thalamic center. In severe hypoxia, there was inhibition of neuron spike activity and a decrease in the frequency of respiration, which became superficial; in these conditions, the inhibitory effect of the thalamus was insignificant.