Signaling and functions of angiopoietin-1 in vascular protection.
Signaling and functions of angiopoietin-1 in vascular protection.
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DOI：
10.1161/01.res.0000218275.54089.12
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发表时间：
2006-04-28
影响因子：
20.1
通讯作者：
Alitalo K
中科院分区：
文献类型：
--
作者：
Brindle NP;Saharinen P;Alitalo K
血管生成素-1具有强大的血管保护作用，抑制血浆渗漏，抑制血管炎症和防止内皮细胞死亡。临床前研究表明，Ang 1可能在许多情况下具有治疗作用，包括治疗水肿、内毒素血症和移植动脉硬化。然而，该配体还涉及血管重塑、诱导血管生成和肺动脉高压，这表明可能需要在优化血管保护的同时使任何有害作用最小化的策略。本文综述了Ang 1的血管保护作用的已发表数据，并强调了这种配体的治疗潜力，以及其使用的可能限制。我们还考虑了Ang 1受体的数据，并推测如何通过靶向Tie受体来最大化治疗益处。
Angiopoietin-1 has powerful vascular protective effects, suppressing plasma leakage, inhibiting vascular inflammation and preventing endothelial death. Pre-clinical studies indicate that Ang1 may be therapeutically useful in a number of situations, including treatment of oedema, endotoxaemia and transplant arteriosclerosis. However, the ligand has also been implicated in vessel remodelling, induction of angiogenesis and pulmonary hypertension, indicating that strategies to minimize any deleterious effects whilst optimizing vessel protection are likely to be needed. This Review surveys the published data on vascular protective effects of Ang1 and highlights the therapeutic potential of this ligand, as well as possible limitations to its use. We also consider the data on Ang1 receptors and speculate on how to maximize therapeutic benefit by targeting the Tie receptors.