Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae).
Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae).
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DOI：
10.1002/jps.2600750324
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发表时间：
1986-03
影响因子：
3.8
通讯作者：
S. Wong;Y. Oshima;J. Pezzuto;H. Fong;N. Farnsworth
中科院分区：
文献类型：
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作者：
S. Wong;Y. Oshima;J. Pezzuto;H. Fong;N. Farnsworth
利用蝴蝶花的根，分离和鉴定了两个已知的三萜类化合物：异虹膜锗醛和玉米素。根据目前的报道，它们对培养的P-388细胞具有细胞毒活性(ED50分别为0.1和1.1微克/毫升)。此外，还分离到一个新的三萜类化合物，其ED50为8.5微克/毫升。经波谱分析和与玉米素的化学关联，确定其结构为6 6 alpha-hydroxy-A‘-neogermmacer-22(29)-en-30-oic酸(米苏林)。
Employing the roots of Iris missouriensis, two known triterpenes, iso-iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P-388 cells (ED50 = 0.1 and 1.1 microgram/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 micrograms/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6 6 alpha-hydroxy-A'-neogermmacer-22(29)-en-30-oic acid (missourin).