Epidemiology of human papillomavirus infection among fishermen along lake victoria shore in the kisumu district, Kenya
Epidemiology of human papillomavirus infection among fishermen along lake victoria shore in the kisumu district, Kenya
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DOI：
10.1136/sti.2007.027508
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发表时间：
2007-02-01
影响因子：
3.6
通讯作者：
Holmes, K. K.
中科院分区：
文献类型：
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作者：
Ng'ayo, M. O.;Bukusi, E.;Holmes, K. K.
目的：肯尼亚男性人乳头瘤病毒（HPV）感染的流行病学特征基本上没有。我们着手确定性活跃的渔民之间的HPV感染的患病率和决定因素沿维多利亚湖在基苏穆区Keny.Methods：生殖器拭子从250个同意渔民从18个海滩和一个详细的社会人口调查问卷进行了管理。HPV阳性通过聚合酶链反应扩增确定，并通过与通用HPV和β-珠蛋白探针的斑点杂交检测。结果：144例（57.6%）渔民中检出HPV DNA，其中106例（42.4%）为致癌型HPV，以HPV-16型最常见（12.4%）。在HPV阳性男性中，105人（72.9%）感染了一种以上的HPV类型，20人（13.9%）感染了六种以上的不同类型。HIV血清阳性男性（PR 1.49，95% CI 1.19至1.86）和离婚或分居者（PR 1.62，95% CI 1.13至2.33）更容易感染HPV。HIV感染（PR 1.22，95% CI 1.01 ~ 1.47）是唯一与多种HPV感染独立相关的因素。结论：该人群中致癌性HPV感染率较高，且与HIV血清学状态和婚姻状况有关。加强性传播感染和艾滋病毒预防干预措施可使这一社区受益。
Objectives: The epidemiology of human papillomavirus (HPV) infection in men in Kenya is largely uncharacterised. We set out to determine the prevalence and determinants of HPV infection among sexually active fishermen along Lake Victoria in the Kisumu district of Kenya.Methods: Genital swabs were obtained from 250 consenting fishermen from 18 beaches and a detailed sociodemographic questionnaire was administered. HPV positivity was determined by polymerase chain reaction amplification and detected by dot blot hybridisation with generic HPV and beta-globin probes. HPV positive samples were genotyped using the Roche Linear array assay.Results: Overall, 144 (57.6%) fishermen had detectable HPV DNA, 106 (42.4%) were infected with oncogenic HPV types, with HPV-16 being the most frequent type (12.4%). Among HPV positive men, 105 (72.9%) were infected with more than one HPV type and 20 (13.9%) were infected with more than six different types. HIV seropositive men (PR 1.49, 95% CI 1.19 to 1.86) and those divorced or separated (PR 1.62, 95% CI 1.13 to 2.33) were more likely to be infected with HPV. HIV infection (PR 1.22, 95% CI 1.01 to 1.47) was the only factor independently associated with infection with multiple types of HPV.Conclusion: The prevalence of oncogenic HPV infection is high among this population and is associated with HIV serostatus and marital status. This community could benefit from enhanced sexually transmitted infection and HIV prevention interventions.