Serum Fibroblast Growth Factor 23 Is a Useful Marker to Distinguish Vitamin D-Deficient Rickets from Hypophosphatemic Rickets.
Serum Fibroblast Growth Factor 23 Is a Useful Marker to Distinguish Vitamin D-Deficient Rickets from Hypophosphatemic Rickets.
复制标题
血清成纤维细胞生长因子 23 是区分维生素 D 缺乏性佝偻病和低磷性佝偻病的有用标志物。
DOI：
10.1159/000357142
复制
发表时间：
2014
影响因子：
3.2
通讯作者：
Ozono K.
中科院分区：
文献类型：
--
作者：
Kubota T;Kitaoka T;Miura K;Fujiwara M;Ohata Y;Miyoshi Y;Yamamoto K;Takeyari S;Yamamoto T;Namba N;Ozono K.
背景/目的维生素D缺乏性佝偻病（DR）最近在发达国家重新出现。维生素D缺乏可影响成纤维细胞生长因子23（FGF 23）相关的遗传性低磷血症性佝偻病（HR）患者的生化结果，使鉴别诊断困难。在本研究中，我们评估的效用血清FGF 23水平在DR的诊断，并在其treatment.MethodsThe研究组包括24名儿童与DR和8名儿童与HR. Serum FGF 23水平和骨代谢相关的measurements进行了assessed.ResultsSerum FGF 23水平在DR患者小于19 pg/ml，而在HR患者超过57 pg/ml。DR和HR患者的血清钙、磷酸盐、甲状旁腺激素和1，25-二羟维生素D水平以及肾小管最大磷酸盐重吸收/肾小球滤过率存在显著差异，但这些值并不完全相互排斥。此外，血清FGF 23和磷酸盐水平的增加，以下treatment.ConclusionSerum FGF 23水平是最关键的生化标志物区分DR从HR和可能是一个很好的指标的生化反应的干预。血清FGF 23水平显示出用于诊断DR和评估其对治疗的反应的实用性。
Background/AimsVitamin D-deficient rickets (DR) has recently re-emerged among developed countries. Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult. In the present study we evaluated the utility of serum FGF23 levels in the diagnosis of DR and during its treatment.MethodsThe study group comprised 24 children with DR and 8 children with HR. Serum FGF23 levels and bone metabolism-related measurements were assessed.ResultsSerum FGF23 levels in patients with DR were less than 19 pg/ml, while those in patients with HR were more than 57 pg/ml. There were significant differences in serum levels of calcium, phosphate, parathyroid hormone, and 1, 25-dihydroxyvitamin D, as well as tubular maximum phosphate reabsorption per glomerular filtration rate between patients with DR and HR, but these values were not fully mutually exclusive. In addition, serum FGF23 and phosphate levels were increased following treatment.ConclusionSerum FGF23 level is the most critical biochemical marker for distinguishing DR from HR and might be a good indicator of biochemical response to the intervention. Serum FGF23 levels show utility for the diagnosis of DR and in the assessment of its response to treatment.