Noninvasive measurement of absolute renal perfusion by contrast medium-enhanced magnetic resonance imaging
Noninvasive measurement of absolute renal perfusion by contrast medium-enhanced magnetic resonance imaging
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DOI：
10.1097/01.rli.0000077127.11949.8c
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发表时间：
2003-09-01
影响因子：
6.7
通讯作者：
Vallée, JP
中科院分区：
文献类型：
--
作者：
Montet, X;Ivancevic, MK;Vallée, JP
目的：本研究的目的是验证动态磁共振成像(MRI)和造影剂定量测量肾脏绝对血流灌注(R-P)的有效性。方法：在新西兰大白兔的左肾动脉周围放置与MR兼容的超声实时血流探头。用动态MRI和静脉注射加多特里多测定基础状态、肾动脉机械性狭窄、静注多巴胺、血管紧张素II或胶体输注时的绝对RP。这一结果与通过定时流动探头在磁体内测量的肾动脉血流相关联。对于信号强度浓度转换，我们根据相位对比序列测量到的不同的动脉血流速度进行了不同的校准，以校正流入效应。用最大上斜率法计算MRI的Rp(单位：毫升/分钟)，Rp/体积定义为皮质增强斜率与动脉输入函数最大值的比值。结果：获得了具有良好对比噪声比的重复性动脉和肾脏传输曲线。与超声实时血流探头相比，MRI显示的血流灌注量被系统性低估，但与这些指标呈线性相关(r=0.80，P
Objective: The aim of this study was to validate the quantification of absolute renal perfusion (R-P) determined by dynamic magnetic resonance imaging (MRI) and contrast media using an experimental model in the rabbit and a transit-timed ultrasound flow probe around the left renal artery as comparison.Material and Methods: An MR-compatible ultrasonic time-of-flight flow-probe was placed around the left renal artery in 9 new Zealand white rabbits. Absolute RP in basal state, after mechanical renal artery stenosis, intravenous dopamine, angiotensin II, or colloid infusion was measured using dynamic MRI and intravenous injection of gadoteridol. The results were correlated to the renal artery flow measured inside the magnet with the transit-timed flow-probe. For the signal intensity concentration conversion, we applied different calibrations according to various velocities measured in the aorta by a phase contrast sequence to correct for inflow effect. MRI-derived RP (in mL/min) was calculated by the maximum upslope method, where RP/volume was defined as the ratio of the cortex contrast enhancement slope over the maximum of the arterial input function determined in the aorta.Results: Reproducible arterial and renal transit curve with excellent contrast to noise ratio were obtained. The MRI derived perfusion was systematically underestimated by comparison to the ultrasonic transit-timed flow-probe but was linearly correlated with these measures (r=0.80, P