Development and investigation of the acoustic properties of tissue-mimicking materials for photoacoustic imaging techniques
Development and investigation of the acoustic properties of tissue-mimicking materials for photoacoustic imaging techniques
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用于光声成像技术的组织模拟材料的声学特性的开发和研究
DOI：
10.1109/ultsym.2019.8926203
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
B. Zeqiri
中科院分区：
文献类型：
--
作者：
Aoife M. Ivory;Anant Shah;S. Rajagopal;B. Zeqiri
体模测试设备用于医学成像模式的开发，以更全面地了解潜在的物理过程并优化技术。目前没有标准的光声成像（派）体模，尽管有朝着标准化的趋势，特别是在新的国际联盟（IPASC）中，该联盟专注于派技术和体模的标准化。在派中使用油材料中的凝胶蜡/共聚物是相对较新的，仅进行了有限的研究，但是由于易于制备和广泛的组件可用性，此类材料有望作为体模材料广泛采用。该材料的标准化制备方法尚未公布。这项工作描述了调查的各种准备的散装材料的声学特性。最终材料由84.49%矿物油（轻质）、12%聚苯乙烯-嵌段-聚（乙烯-然-丁烯）-嵌段-聚苯乙烯3%低密度聚乙烯、0.05%TiO 2和0.46%苯扎氯铵，并且在6个月内具有模拟脂肪软组织的稳定声学特性，相速度为1464.2 ± 0.4 m·s-1，平均衰减为4.04 ± 0.2 dB·cm-1（5 MHz）。
Phantom test devices are used in the development of medical imaging modalities to gain a more complete understanding of the underlying physical processes and to optimize techniques. There are currently no standard photoacoustic imaging (PAI) phantoms, although there is a move towards standardization, notably in a new international consortium (IPASC) focusing on the standardization of PAI techniques and phantoms. The use of gel wax/copolymer in oil materials in PAI is relatively recent with only limited studies carried out, however such materials hold promise for wide-spread adoption as a phantom material due to ease of preparation and extensive component availability. A standardized preparation method for the material has yet to be published. This work describes an investigation of the acoustic properties of various preparations of the bulk material. The final material consisted of 84.49 % mineral oil (light), 12 % Polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene 3 % low density polyethylene, 0.05 % TiO2 and 0.46 % Benzalkonium chloride and had stable acoustic properties mimicking fatty soft tissue over 6 months, with a phase velocity of 1464.2 ± 0.4 m s‒1 and mean attenuation of 4.04 ± 0.2 dB cm‒1 at 5 MHz.