Urinary Biomarkers of Brain Diseases.
Urinary Biomarkers of Brain Diseases.
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DOI：
10.1016/j.gpb.2015.08.005
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Gao Y
中科院分区：
文献类型：
--
作者：
An M;Gao Y
生物标志物是与生理或病理生理过程相关的可测量的变化。与血液不同，尿液不受体内平衡机制的影响。因此，尿液中的波动可能比血液中的波动更大，更能反映人体的变化。提出了尿液生物标志物时代的路线图。虽然尿液分析已被尝试用于临床诊断，并且在许多疾病，特别是泌尿系统疾病的进展期间监测尿液，但尿液是否能反映脑部疾病状态仍不确定。由于脑疾病的一些生物标志物可以在体液如脑脊液和血液中检测到，因此尿液也可能含有脑疾病的生物标志物。本文就尿蛋白质组和代谢物组反映的脑疾病线索作一综述。
Biomarkers are the measurable changes associated with a physiological or pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clinical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood, there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome.