Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C
Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C
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DOI：
10.1097/rhu.0b013e3181775e80
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发表时间：
2008-06-01
影响因子：
3.4
通讯作者：
Terry, Shaughan
中科院分区：
文献类型：
--
作者：
Ho, Vincent;Mclean, Anna;Terry, Shaughan
我们报告一例43岁男性患者，在接受聚乙二醇干扰素和利巴韦林治疗慢性丙型肝炎后发生系统性红斑狼疮。他表现出美国风湿病学会SLE标准的8个特征：肾小球肾炎、关节炎、浆膜炎、鲜红盘状皮疹、淋巴细胞减少、口腔溃疡、高滴度抗核抗体和抗双链DNA抗体的产生。此外，他的入院并发了危及生命的心肌心包炎和血管炎。该病例值得注意的是丙型肝炎抗病毒治疗引起的多器官狼疮的临床严重程度和性质。SLE的临床体征已消退，抗DS DNA已正常化。
We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.