Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.
Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.
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DOI：
10.1021/acs.bioconjchem.6b00405
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发表时间：
2016-11-16
影响因子：
4.7
通讯作者：
Kingston DG
中科院分区：
文献类型：
--
作者：
Paciotti GF;Zhao J;Cao S;Brodie PJ;Tamarkin L;Huhta M;Myer LD;Friedman J;Kingston DG
一系列硫醇化紫杉醇类似物的合成被描述为一种新型纳米医学计划的一部分，该计划旨在开发将与金纳米颗粒结合用于肿瘤靶向药物递送的紫杉醇制剂。初步评估的新纳米药物组成的27纳米金纳米粒子，肿瘤坏死因子α（TNFα），硫醇化聚乙二醇（PEG-硫醇）和几个硫醇化紫杉醇类似物之一。
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine comprised of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-Thiol) and one of several thiolated paclitaxel analogs is presented.