Cerebral benzodiazepine receptors in hippocampal sclerosis - An objective in vivo analysis
Cerebral benzodiazepine receptors in hippocampal sclerosis - An objective in vivo analysis
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DOI：
10.1093/brain/119.5.1677
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发表时间：
1996-10-01
期刊：
影响因子：
14.5
通讯作者：
Duncan, JS
中科院分区：
文献类型：
--
作者：
Koepp, MJ;Richardson, MP;Duncan, JS
我们使用[C-11]氟马西尼 (FMZ)-PET 和高分辨率体积 MRI 客观地描述了 12 名伴有单侧海马硬化的内侧颞叶癫痫 (mTLE) 患者中枢苯二氮卓受体 (cBZR) 结合的异常程度，这些患者接受了术前评估和随后的颞叶手术。我们使用统计参数映射 (SPM) 比较了从 17 名健康对照者的个体和 [C-11]FMZ-V-d 患者组获得的局部脑部 [C-11]FMZ 分布体积 (V-d) 的参数 3D 图像。在 12 名单侧海马硬化患者中，受影响海马的 [C-12]FMZ-V-d 显着降低（P < 0.001）。对个体患者的分析反映了小组的发现，任何患者的海马外 cBZR 结合均未出现显着异常。我们得出的结论是，SPM 是检测区域大脑 [C-11]FMZ 结合变化的有用客观方法，并且在 mTLE 和单侧海马硬化患者中，cBZR 结合的减少仅限于海马硬化区域，在颞新皮质或新皮质其他部位未检测到异常。
We objectively delineated the extent of abnormalities in central benzodiazepine receptor (cBZR) binding using [C-11]flumazenil (FMZ)-PET and high resolution volumetric MRI in 12 patients with mesial temporal lobe epilepsy (mTLE) associated with unilateral hippocampal sclerosis, who underwent presurgical evaluation and subsequent temporal lobe surgery. We compared parametric 3D-images of regional cerebral [C-11]FMZ volume of distribution (V-d) obtained from individuals and groups of patients with [C-11]FMZ-V-d from a group of 17 healthy controls using statistical parametric mapping (SPM). The [C-12]FMZ-V-d was significantly reduced (P < 0.001) in the affected hippocampus in the group of 12 patients with unilateral hippocampal sclerosis. Analysis of individual patients reflected the group finding and there was no significant abnormality of cBZR binding outside the hippocampus in any patient. We conclude that SPM is an useful objective method for detecting changes in regional cerebral [C-11]FMZ binding and that in patients with mTLE and unilateral hippocampal sclerosis reduction of cBZR binding is restricted to the area of hippocampal sclerosis with no abnormalities being detected in the temporal neocortex or elsewhere in the neocortex.