Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer
Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer
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DOI：
10.1111/j.1349-7006.2009.01381.x
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Shimada, Hideaki
中科院分区：
文献类型：
--
作者：
Kawahira, Hiroshi;Matsushita, Kazuyuki;Shimada, Hideaki
We detected adenoviral DNA fragments in excretions of 10 esophageal cancer patients by DNA-PCR after tumor injection of Ad-CMV-vector. A total of 220 samples consisting of feces, gargling saliva, urine, and blood plasma were assessed. A total of 29.7% of feces samples and 13.2% of gargling saliva samples were positive for adenoviral DNA fragments, but 89.7% of the positive feces samples and all of the positive gargling saliva samples turned negative on day 12 after tumor injection. Although adenoviral DNA fragments may be pathogen-free, patients' feces and gargling saliva contain adenoviral DNA fragments for 12 days after injection. (Cancer Sci 2010; 101: 289-291).
