Mechanotransduction in bone - role of the lacuno-canalicular network
Mechanotransduction in bone - role of the lacuno-canalicular network
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DOI：
10.1096/fasebj.13.9001.s101
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发表时间：
1999-01-01
期刊：
影响因子：
4.8
通讯作者：
Klein-Nulend, J
中科院分区：
文献类型：
--
作者：
Burger, EH;Klein-Nulend, J
人们早已认识到骨组织改变其质量和结构以响应机械需求的能力，但所涉及的细胞机制仍然知之甚少。过去几年来，这一领域取得了重大进展，我们将对其进行总结。这些研究强调了骨细胞作为骨的专业机械感觉细胞的作用，以及腔隙小管孔隙作为介导机械感觉的结构的作用。应变产生的间质液通过这种孔隙的流动似乎机械地激活了骨细胞，并确保了细胞信号分子、营养物质和废物的运输。这个概念可以解释局部骨的增加和减少，以及响应疲劳损伤的重塑，作为由机械敏感骨细胞监督的过程。
The capacity of bone tissue to alter its mass and structure in response to mechanical demands has long been recognized but the cellular mechanisms involved remained poorly understood. Over the last several years significant progress has been made in this field, which we will try to summarize. These studies emphasize the role of osteocytes as the professional mechanosensory cells of bone, and the lacuno-canalicular porosity as the structure that mediates mechanosensing. Strain-derived flow of interstitial fluid through this porosity seems to mechanically activate the osteocytes, as well as ensuring transport of cell signaling molecules and nutrients and waste products. This concept allows an explanation of local bone gain and loss, as well as remodeling in response to fatigue damage, as processes supervised by mechanosensitive osteocytes.