NMDA receptor antagonists block the induction of long-term depression in the hippocampal dentate gyrus of the anesthetized rat.
NMDA receptor antagonists block the induction of long-term depression in the hippocampal dentate gyrus of the anesthetized rat.
复制标题
NMDA 受体拮抗剂可阻断麻醉大鼠海马齿状回长期抑郁的诱导。
DOI：
10.1016/0006-8993(91)90664-h
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Levy,WB
中科院分区：
文献类型：
--
作者：
Desmond,NL;Colbert,CM;Zhang,DX;Levy,WB
The present study tested the effect of two non-competitive NMDA receptor antagonists, ketamine and phencyclidine, on the induction of long-term depression (LTD) in the dentate gyrus of urethane-anesthetized rats. Both drugs blocked the induction of LTD as well as long-term potentiation (LTP). NMDA receptor activation thus seems to be required for the induction of both LTD and LTP in the dentate gyrus. High-intensity conditioning stimulation did not overcome the phencyclidine block of LTD. Strong, but brief, postsynaptic depolarization is apparently not the only event needed to trigger LTD.
