The UAE healthy future study: a pilot for a prospective cohort study of 20,000 United Arab Emirates nationals
The UAE healthy future study: a pilot for a prospective cohort study of 20,000 United Arab Emirates nationals
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DOI：
10.1186/s12889-017-5012-2
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发表时间：
2018-01-05
影响因子：
4.5
通讯作者：
Ali, Raghib
中科院分区：
文献类型：
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作者：
Abdulle, Abdishakur;Alnaeemi, Abdullah;Ali, Raghib
背景：阿拉伯联合酋长国（UAE）面临着包括肥胖、糖尿病和心血管疾病在内的非传染性疾病负担迅速增加的问题。阿联酋健康未来研究是一项前瞻性队列研究，旨在确定阿联酋人中危险因素与这些疾病之间的关联。这项研究将招募2万名18岁的阿联酋国民。将描述环境和遗传风险因素，并对参与者进行随访，以了解未来的疾病事件。由于这是阿联酋首次计划进行前瞻性队列研究，因此于2015年进行了一项试点研究，主要目的是确定开展该研究的可行性。其他目标是评估主要研究方案的实施情况，并建立足够的能力进行先进的临床实验室分析。方法：邀请769名年龄在bb0 = 18岁的阿联酋国民自愿参加试点研究。参与者签署了一份知情同意书，完成了一份详细的调查问卷，随机提供了血液、尿液和漱口水样本，并接受了一系列临床指标的评估。所有标本都被运送到纽约大学阿布扎比实验室，在那里进行常规化学和血液学处理和分析。血浆、血清和用于DNA提取的少量全血样本被引用并保存在-80℃，以备将来分析。结果：总体而言，517名阿联酋男性和女性同意参与（68%的回复率）。其中，495人（95.0%）、430人（82.2%）和492人（94.4%）完成了问卷调查、体格测量和提供了生物样本。结论：试点研究表明，为旨在确定该区域主要非传染性疾病新出现的风险因素的第一次大规模队列研究招募和完成研究规程是可行的。
Background: The United Arab Emirates (UAE) is faced with a rapidly increasing burden of non-communicable diseases including obesity, diabetes, and cardiovascular disease. The UAE Healthy Future study is a prospective cohort designed to identify associations between risk factors and these diseases amongst Emiratis. The study will enroll 20,000 UAE nationals aged = 18 years. Environmental and genetic risk factors will be characterized and participants will be followed for future disease events. As this was the first time a prospective cohort study was being planned in the UAE, a pilot study was conducted in 2015 with the primary aim of establishing the feasibility of conducting the study. Other objectives were to evaluate the implementation of the main study protocols, and to build adequate capacity to conduct advanced clinical laboratory analyses.Methods: Seven hundred sixty nine UAE nationals aged >= 18 years were invited to participate voluntarily in the pilot study. Participants signed an informed consent, completed a detailed questionnaire, provided random blood, urine, and mouthwash samples and were assessed for a series of clinical measures. All specimens were transported to the New York University Abu Dhabi laboratories where samples were processed and analyzed for routine chemistry and hematology. Plasma, serum, and a small whole blood sample for DNA extraction were aliquoted and stored at -80 degrees C for future analyses.Results: Overall, 517 Emirati men and women agreed to participate (68% response rate). Of the total participants, 495 (95.0%), 430 (82.2%), and 492 (94.4%), completed the questionnaire, physical measurements, and provided biological samples, respectively.Conclusions: The pilot study demonstrated the feasibility of recruitment and completion of the study protocols for the first large-scale cohort study designed to identify emerging risk factors for the major non-communicable diseases in the region.