Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users
Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users
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DOI：
10.1016/j.drugalcdep.2004.03.006
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发表时间：
2004-09-06
影响因子：
4.2
通讯作者：
Curran, HV
中科院分区：
文献类型：
--
作者：
Morgan, CJA;Riccelli, M;Curran, HV
依据：氯胺酮是一种N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，越来越多地用作娱乐性药物。先前的研究表明，在长期使用氯胺酮的患者中，总体广义言语记忆障碍持续3天，但在这一人群中尚未专门研究情景记忆。目的：确定氯胺酮在用药当晚（第0天）和3天后是否与通过源记忆任务评估的情节记忆受损相关。方法：20名氯胺酮使用者和20名多药对照者在第0天和第3天进行源记忆任务比较。参与者还在两天内完成了索引精神分裂症样症状和分离症状的问卷调查。结果如下：在第0天，氯胺酮滥用者的源记忆和项目识别受损，精神分裂症和分离症状量表得分更高相比，多种药物对照。在第3天，氯胺酮滥用者仅表现出源记忆障碍，这些与第0天的精神分裂症样症状水平呈正相关。在第3天没有观察到精神分裂症样或分离症状的差异。结论：氯胺酮滥用者在第3天的源记忆中表现出持续的缺陷，但在项目识别中没有。这些发现表明，反复使用氯胺酮会对情景记忆产生慢性损害。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Rationale: Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that is increasingly being used as a recreational drug. Previous research has shown gross generalised verbal memory impairments persisting 3 days after ketamine use in chronic users, however episodic memory has not specifically investigated in this population. Objective: To determine whether ketamine, on the night of drug use (day 0) and 3 days later, is associated with impaired episodic memory as assessed by a source memory task. Methods: Twenty ketamine users and 20 poly-drug controls were compared on a source memory task both on day 0 and 3. Participants also completed questionnaires on both days indexing schizophrenic-like and dissociative symptoms. Results: On day 0, ketamine abusers were impaired on both source memory and item recognition and scored more highly on schizophrenic and dissociative symptom scales compared to poly-drug controls. On day 3 ketamine abusers only displayed source memory impairments and these positively correlated with the level of schizophrenic-like symptoms on day 0. No differences on day 3 in schizophrenic-like or dissociative symptoms were observed. Conclusions: Ketamine abusers exhibit a persisting deficit in source memory on day 3 but not in item recognition. These findings suggest that repeated use of ketamine produces chronic impairments to episodic memory. (C) 2004 Elsevier Ireland Ltd. All rights reserved.