Differentiation towards gastric foveolar, mucopeptic and intestinal goblet cells in gallbladder adenocarcinomas
Differentiation towards gastric foveolar, mucopeptic and intestinal goblet cells in gallbladder adenocarcinomas
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DOI：
10.1046/j.1365-2559.1996.d01-520.x
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发表时间：
1996-11-01
期刊：
影响因子：
6.4
通讯作者：
Borchard, F
中科院分区：
文献类型：
--
作者：
Kushima, R;Lohe, B;Borchard, F
使用胃小凹细胞 (M1)、(假) 幽门细胞 (M2) 和肠杯状细胞 (MS) 粘蛋白特异性抗体，以及胃蛋白酶原 II 和嗜铬粒蛋白 A 抗体，对 22 例手术切除的胆囊腺癌的细胞分化进行了免疫组织化学研究。超过 70% 的肿瘤（22 例中的 16 例）表现出胃型和/或肠型分化，其中大多数（16 例中的 12 例）显示两种类型的分化。两个肿瘤表现出与正常胃粘膜相似的类器官生长模式，嗜铬粒蛋白A阳性的内分泌细胞的存在与胃和/或肠型细胞的存在密切相关。目前的研究结果清楚地表明胆囊腺癌的多向分化，并表明大多数胆囊腺癌在胃和肠分化的诱导下发生和进展。
Cellular differentiation in 22 surgically removed adenocarcinomas of the gallbladder was immunohistochemically studied with antibodies specific to mucins of gastric foveolar cells (M1), (pseudo)pyloric cells (M2) and intestinal goblet cells (MS), and also with antibodies against pepsinogen II and chromogranin A. More than 70% of tumours (16 of 22 cases) displayed gastric- and/or intestinal-type differentiation, most of which (12 of 16 cases) showed both types of differentiation. Two tumours showed an organoid growth pattern similar to the normal gastric mucosa, The presence of endocrine cells positive for chromogranin A was closely related to that of gastric- and/or intestinal-type cells. The present findings clearly indicate the multidirectional differentiation of gallbladder adenocarcinomas and suggest that most gallbladder adenocarcinomas develop and progress under induction of gastric and intestinal differentiation.