The general characteristics of acute urticaria attacks and the factors predictive of progression to chronic urticaria
The general characteristics of acute urticaria attacks and the factors predictive of progression to chronic urticaria
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DOI：
10.1016/j.aller.2012.05.007
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发表时间：
2013-07-01
影响因子：
1.8
通讯作者：
Kalyoncu, A. F.
中科院分区：
文献类型：
--
作者：
Comert, S.;Celebioglu, E.;Kalyoncu, A. F.
背景：从急性荨麻疹（Au）进展为慢性荨麻疹（CU）的自然史仍然知之甚少。本研究旨在探讨潜在的触发因素的Au攻击和相关的因素，其持续时间，以及可能是预测进展到CU.Methods的因素：本研究包括281 Au患者（Au组）。从207例Au患者中回顾性获得数据，从74例Au患者中前瞻性获得数据。CU组由953例患者组成，其数据先前published.Results：根据病史，最常见的潜在触发Au发作的药物（38.1%），感染（35.2%），压力（24.7%）和食物（17.8%）。在食物（p = 0.04）或感染（p = 0.04）是疑似触发因素的病例中，发作持续时间较短。有鼻炎（p = 0.04）和食物过敏（p = 0.04）病史，花粉（p = 0.02）和狗（p = 0.02）皮肤点刺试验结果阳性的患者也有较短的发作时间。哮喘患者发作持续时间较长（p = 0.01）。根据病史和/或激发试验结果，CU组的非甾体类抗炎药超敏反应（NSAID）患病率显著高于Au组（24.9% vs.4.3%，P < 0.01），抗生素过敏也是如此（分别为10.6%对4.6%，（p < 0.01））和食物过敏（分别为18.3%对3.9%，（p < 0.01））。NSAID（或：7.97; 95%可信区间：4.33-14.66; p < 0.01）和食物过敏（OR：5.17; 95%CI：2.71-9.85; p < 0.01）是CU的独立相关因素。结论：由于NSAIDH和食物过敏与CU相关，因此在Au患者中应仔细评估它们的存在以预测CU的进展。(C)2012年SEICAP。出版社：Elsevier Espana，S.L. All rights reserved.
Background: The natural history of progression from acute urticaria (AU) to chronic urticaria (CU) remains poorly understood. This study aimed to investigate the potential triggers of AU attacks and factors associated with their duration, as well as the factors which may be predictive of progression to CU.Methods: The study included 281 AU patients (AU group). Data were obtained from 207 AU patients retrospectively and from 74 AU patients prospectively. The CU group consisted of 953 patients, whose data were previously published.Results: According to the medical history, the most common potential triggers of AU attacks were drugs (38.1%); infections (35.2%); stress (24.7%); and foods (17.8%). Attack duration was shorter in cases in which food (p = 0.04) or infection (p = 0.04) was the suspected trigger. Patients with a history of rhinitis (p = 0.04) and food allergy (p = 0.04), and positive skin prick test results for pollens (p = 0.02) and dog (p = 0.02) also had attacks of shorter duration. Patients with asthma had attacks of longer duration (p = 0.01). Based on history and/or provocation test results, the prevalence of non-steroidal anti-inflammatory drug hypersensitivity (NSAIDH) was significantly higher in the CU group than the AU group (24.9% vs. 4.3%, respectively, (p < 0.01)), as was antibiotic hypersensitivity (10.6% vs. 4.6%, respectively, (p < 0.01)) and food allergy (18.3% vs. 3.9%, respectively, (p < 0.01)). NSAIDH (OR: 7.97; 95%CI: 4.33-14.66; p < 0.01) and food allergy (OR: 5.17; 95%CI: 2.71-9.85; p < 0.01) were observed to be independent factors associated with CU.Conclusions: As NSAIDH and food allergy were associated with CU, their presence should be carefully evaluated in patients with AU in order to predict progression to CU. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.