Three-wavelength murine photoplethysmography for estimation of vascular gold nanorod concentration.
Three-wavelength murine photoplethysmography for estimation of vascular gold nanorod concentration.
复制标题
三波长鼠光电体积描记法用于估计血管金纳米棒浓度。
DOI：
10.1364/oe.18.026535
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发表时间：
2010
期刊：
影响因子：
3.8
通讯作者：
D. O'Neal
中科院分区：
文献类型：
--
作者：
G. Michalak;J. Schwartz;Glenn P. Goodrich;D. O'Neal
纳米粒子辅助光热（NAPT）消融术已成为一种新的和有吸引力的模式，用于治疗癌性肿瘤。这种疗法利用静脉内递送的光学共振金属纳米颗粒在肿瘤中的被动积累，然而，这些颗粒的循环生物利用度通常是未知的。我们提出了一种非侵入性的光学设备，能够监测光学共振金纳米棒的流通。该设备被称为脉冲光度计，使用多波长光电体积描记技术。我们同时报告了金纳米棒的循环和血氧测定法在没有麻醉的小鼠中注射后6小时的循环，并且在不收集数据时移除探针。该仪器与血液样品的离体分光光度分析显示出良好的一致性（R（2）= 0.903，n = 30）。所提供的实时反馈具有降低变异性的强大潜力，从而提高类似临床治疗的疗效。
Nanoparticle-assisted photo-thermal (NAPT) ablation has become a new and attractive modality for the treatment of cancerous tumors. This therapy exploits the passive accumulation of intravenously delivered optically resonant metal nanoparticles into tumors, however, the circulating bioavailability of these particles is often unknown. We present a non-invasive optical device capable of monitoring the circulation of optically resonant gold nanorods. The device, referred to as a pulse photometer, uses the technique of multi-wavelength photoplethysmography. We simultaneously report the circulation of gold nanorods and oximetry for six hours post-injection in mice with no anesthesia and remove the probe when not collecting data. The instrument shows good agreement (R(2) = 0.903, n = 30) with ex vivo spectrophotometric analysis of blood samples. The real-time feedback provided has a strong potential for reducing variability and thus improving the efficacy of similar clinical therapies.