Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: A controlled clinical study
Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: A controlled clinical study
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DOI：
10.1111/j.1528-1167.2012.03626.x
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发表时间：
2012-10-01
期刊：
影响因子：
5.6
通讯作者：
Wang, Yuping
中科院分区：
文献类型：
--
作者：
Sun, Wei;Mao, Wei;Wang, Yuping
目的：本研究旨在评价低频重复经颅磁刺激（rTMS）治疗难治性部分性癫痫的疗效。研究方法：筛选出64例难治性局灶性癫痫患者，其中60例按刺激强度随机分为静息运动阈值（rMT）的90%（1组）和20%（2组）。比较基线和随访期间的癫痫发作频率和发作间期EEG癫痫放电。关键发现：与基线水平相比，2周高强度（90% rMT）rTMS治疗后癫痫发作显著减少（p < 0.05）。rTMS组发作间期癫痫放电明显减少，症状自评量表评分明显改善（p < 0.05）。在接受低强度（20%rMT）rTMS的患者中，随访期间的癫痫发作和棘波与基线数据相比没有任何差异（分别为p > 0.05）。重要性：低频高强度rTMS（90%rMT）进入致痫区对难治性部分性发作患者有显着的抗癫痫作用。经颅磁刺激治疗还可减少发作间期癫痫放电频率，改善患者的心理状况。
Purpose: This study was designed to evaluate the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with refractory partial epilepsy. Methods: Sixty-four patients with refractory focal epilepsy were screened and 60 patients were randomly divided into two groups by stimulation intensity: 90% (group 1) or 20% (group 2) of resting motor threshold (rMT). Seizure frequency and interictal EEG epileptic discharges were compared between the baseline and follow-up periods. Key Findings: Seizures significantly decreased following 2-weeks high intensity (90% rMT) rTMS treatment compared with baseline level (p < 0.05). rTMS also decreased interictal epilepsy discharges and improved the scales of Symptom Checklist-90 significantly (p < 0.05). Seizures and spikes in the follow-up period in the patients who received low intensity (20% rMT) rTMS did not show any difference compared with baseline data (p > 0.05, respectively). Significance: Low-frequency high intensity rTMS (90% rMT) delivered into the epileptogenic zone had a significant antiepileptic effect on patients with refractory partial seizures. rTMS treatment can also reduce the interictal epileptic discharge frequency and improve the psychological condition of these patients.