Current Knowledge and Recent Advances of Right Ventricular Molecular Biology and Metabolism from Congenital Heart Disease to Chronic Pulmonary Hypertension.
Current Knowledge and Recent Advances of Right Ventricular Molecular Biology and Metabolism from Congenital Heart Disease to Chronic Pulmonary Hypertension.
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DOI：
10.1155/2018/1981568
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发表时间：
2018
影响因子：
--
通讯作者：
Mercier O
中科院分区：
文献类型：
--
作者：
Guimaron S;Guihaire J;Amsallem M;Haddad F;Fadel E;Mercier O
关于肺动脉高压和先天性心脏病的研究已经引入了右心室重构的概念，导致这些病理导致类似的结果：右心室衰竭。然而，右心室重塑也是一个生理过程，使正常胎儿右心室适应出生并获得其成年表型。健康的成熟右心室暴露于低肺血管阻力并且是顺应性的。然而，在慢性压力超负荷（如肺动脉高压）或容量超负荷（如先天性心脏病）的情况下，右心室恢复到胎儿表型以维持其功能。其机制包括血管生成变化和伴随的代谢活动增加以维持能量产生。最终，重塑的右心室不能抵抗增加的后负荷，导致右心室衰竭。在比较胎儿和成人健康右心室后，我们试图回顾PH和CHD背景下发生的主要代谢和细胞变化。它们与RV功能的关系以及对临床实践的潜在影响也将被讨论。
Studies about pulmonary hypertension and congenital heart diseases have introduced the concept of right ventricular remodeling leading these pathologies to a similar outcome: right ventricular failure. However right ventricular remodeling is also a physiological process that enables the normal fetal right ventricle to adapt at birth and gain its adult phenotype. The healthy mature right ventricle is exposed to low pulmonary vascular resistances and is compliant. However, in the setting of chronic pressure overload, as in pulmonary hypertension, or volume overload, as in congenital heart diseases, the right ventricle reverts back to a fetal phenotype to sustain its function. Mechanisms include angiogenic changes and concomitant increased metabolic activity to maintain energy production. Eventually, the remodeled right ventricle cannot resist the increased afterload, leading to right ventricular failure. After comparing the fetal and adult healthy right ventricles, we sought to review the main metabolic and cellular changes occurring in the setting of PH and CHD. Their association with RV function and potential impact on clinical practice will also be discussed.
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影响因子：
24
作者：
Abraham, WT;Adams, KF;Wynne, J
通讯作者：
Wynne, J
影响因子：
7.5
作者：
Bokhari, Sabahat;Raina, Amresh;Johnson, Lynne L.
通讯作者：
Johnson, Lynne L.
DOI：
10.1136/heartjnl-2015-308348
发表时间：
2016-01
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Iacobazzi D;Suleiman MS;Ghorbel M;George SJ;Caputo M;Tulloh RM
通讯作者：
Tulloh RM
影响因子：
37.8
作者：
Brittain EL;Talati M;Fessel JP;Zhu H;Penner N;Calcutt MW;West JD;Funke M;Lewis GD;Gerszten RE;Hamid R;Pugh ME;Austin ED;Newman JH;Hemnes AR
通讯作者：
Hemnes AR
影响因子：
2.3
作者：
Amsallem M;Kuznetsova T;Hanneman K;Denault A;Haddad F
通讯作者：
Haddad F