Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas
Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas
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DOI：
10.1016/j.jbiomech.2016.11.024
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发表时间：
2017-01-04
影响因子：
2.4
通讯作者：
Sucosky, Philippe
中科院分区：
文献类型：
--
作者：
Cao, Kai;Atkins, Samantha K.;Sucosky, Philippe
二叶式主动脉瓣 (BAV) 产生血流异常，可能会促进主动脉病变。虽然正螺旋分数 (PHF) 指数、流动角 (theta)、流动位移 (d) 和壁剪切应力 (WSS) 在扩张的 BAV 主动脉中表现出异常，但尚不清楚这些异常是否源于异常的瓣膜解剖结构或扩张的主动脉。因此，本研究的目的是量化扩张前不同 BAV 形态类型对主动脉血流动力学的早期影响。流固耦合模型旨在量化与功能性三尖瓣主动脉瓣 (TAV) 和 I 型 BAV 连接的真实非扩张主动脉中的标准峰值收缩流量指标和时间 WSS 特征。虽然 BAV 在中升主动脉 (AA) 中产生增加的螺旋度 (PHF > 0.68)，但相对于 TAV (PHF=0.51；theta) 产生较大的收缩期血流偏度 (theta > 11.2 度) 和位移 (d > 6.8 mm)
Bicuspid aortic valves (BAVs) generate flow abnormalities that may promote aortopathy. While positive helix fraction (PHF) index, flow angle (theta), flow displacement (d) and wall shear stress (WSS) exhibit abnormalities in dilated BAV aortas, it is unclear whether those anomalies stem from the abnormal valve anatomy or the dilated aorta. Therefore, the objective of this study was to quantify the early impact of different BAV morphotypes on aorta hemodynamics prior to dilation. Fluid-structure interaction models were designed to quantify standard peak-systolic flow metrics and temporal WSS characteristics in a realistic non-dilated aorta connected to functional tricuspid aortic valve (TAV) and type-I BAVs. While BAVs generated increased helicity (PHF > 0.68) in the middle ascending aorta (AA), larger systolic flow skewness (theta > 11.2 degrees) and displacement (d > 6.8 mm) relative to the TAV (PHF=0.51; theta