The vascular-ablative agent VEGF121/rGel inhibits pulmonary Metastases of MDA-MB-231 breast tumors
The vascular-ablative agent VEGF121/rGel inhibits pulmonary Metastases of MDA-MB-231 breast tumors
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DOI：
10.1593/neo.04631
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发表时间：
2005-05-01
期刊：
影响因子：
4.8
通讯作者：
Rosenblum, MG
中科院分区：
文献类型：
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作者：
Ran, S;Mohamedali, KA;Rosenblum, MG
血管内皮生长因子(121)/rGel是由生长因子VEGF(121)和重组毒素凝胶(RGel)组成的融合蛋白，靶向肿瘤新生血管，通过抑制蛋白质合成发挥显著的细胞毒作用。我们观察了血管内皮生长因子(121)/rGel对SCID小鼠转移性肿瘤细胞生长的影响。与对照组相比，VEGF(121)/rGel治疗组的体表肺肿瘤灶减少了58%(平均值分别为22.4和53.3；P
VEGF(121)/rGel, a fusion protein composed of the growth factor VEGF(121) and the recombinant toxin gelonin (rGel), targets the tumor neovasculature and exerts impressive cytotoxic effects by inhibiting protein synthesis. We evaluated the effect of VEGF(121)/rGel on the growth of metastatic MDA-MB-231 tumor cells in SCID mice. VEGF(121)/rGel treatment reduced surface lung tumor foci by 58% compared to controls (means were 22.4 and 53.3, respectively; P